Zirconium-Coated β-Cyclodextrin Nanomaterials for Biofilm Eradication

Akanksha Gupta, John H.T. Luong, Aharon Gedanken

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Under alkaline treatment, zirconyl chloride (ZrOCl2.8H2O) became a zirconia gel and formed a stable complex with beta-cyclodextrin (βCD). This complex was highly active in reactive oxygen species (ROS) formation via H2O2 decomposition. Its surface with numerous hydroxyl groups acts as an ionic sponge to capture the charged reaction intermediates, including superoxide (O2-•) and the hydroxyl radical (OH). ROS, especially OH radicals, are harmful to living microorganisms because of their kinetic instability, high oxidation potential, and chemical nonselectivity. Therefore, OH radicals can engage in fast reactions with virtually any adjacent biomolecule. With H2O2, the complex with cationic and hydrophobic moieties interacted with the anionic bacterial membrane of two Gram-positive (Staphylococcus aureus and S. epidermidis) and two Gram-negative (Escherichia coli and Klebsiella pneumoniae) strains. The Zr-βCD-H2O2 also eradicated more than 99% of the biofilm of these four pathogens. Considering the difficult acquisition of resistance to the oxidation of OH, the results suggested that this βCD-based nanomaterial might be a promising agent to target both drug-resistant pathogens with no cytotoxicity and exceptional antimicrobial activity.

Original languageEnglish
Pages (from-to)5470-5480
Number of pages11
JournalACS Applied Bio Materials
Issue number12
StatePublished - 18 Dec 2023

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© 2023 American Chemical Society.


  • ROS generation
  • Zr-coated β-cyclodextrin with HO
  • antibacterial
  • biofilm eradication
  • cytotoxicity


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