When Mathematics Outsmarts Cancer

Somnath Tagore; Milana Frenkel-Morgenstern

doi:10.1007/978-3-030-17938-0_42

When Mathematics Outsmarts Cancer

Somnath Tagore, Milana Frenkel-Morgenstern

Bar-Ilan University - Azrieli Faculty of Medicine

Columbia University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Mathematics has become essential in cancer biology. Recent developments in high-throughput molecular profiling techniques enable assessing molecular states of tumors in great detail. Cancer genome data are collected at a large scale in numerous clinical studies and in international consortia, such as The Cancer Genome Atlas and the International Cancer Genome Consortium. Developing mathematical models that are consistent with and predictive of the true underlying biological mechanisms is a central goal of cancer biology. In this work, we used percolations and power-law models to study protein-protein interactions in cancer fusions. We used site-directed knockouts to understand the modular components of fusion protein-protein interaction networks, thereby providing models for target-based drug predictions.

Original language	English
Title of host publication	Bioinformatics and Biomedical Engineering - 7th International Work-Conference, IWBBIO 2019, Proceedings
Editors	Olga Valenzuela, Francisco Ortuño, Ignacio Rojas, Francisco Ortuño, Fernando Rojas
Publisher	Springer Verlag
Pages	477-485
Number of pages	9
ISBN (Print)	9783030179373
DOIs	https://doi.org/10.1007/978-3-030-17938-0_42
State	Published - 2019
Event	7th International Work-Conference on Bioinformatics and Biomedical Engineering, IWBBIO 2019 - Granada, Spain Duration: 8 May 2019 → 10 May 2019

Publication series

Name	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume	11465 LNBI
ISSN (Print)	0302-9743
ISSN (Electronic)	1611-3349

Conference

Conference	7th International Work-Conference on Bioinformatics and Biomedical Engineering, IWBBIO 2019
Country/Territory	Spain
City	Granada
Period	8/05/19 → 10/05/19

Bibliographical note

Publisher Copyright:
© 2019, Springer Nature Switzerland AG.

Keywords

Fusion proteins
Protein-protein interaction networks
Site-directed percolations

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-3-030-17938-0_42

Cite this

Tagore, S., & Frenkel-Morgenstern, M. (2019). When Mathematics Outsmarts Cancer. In O. Valenzuela, F. Ortuño, I. Rojas, F. Ortuño, & F. Rojas (Eds.), Bioinformatics and Biomedical Engineering - 7th International Work-Conference, IWBBIO 2019, Proceedings (pp. 477-485). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 11465 LNBI). Springer Verlag. https://doi.org/10.1007/978-3-030-17938-0_42

Tagore, Somnath ; Frenkel-Morgenstern, Milana. / When Mathematics Outsmarts Cancer. Bioinformatics and Biomedical Engineering - 7th International Work-Conference, IWBBIO 2019, Proceedings. editor / Olga Valenzuela ; Francisco Ortuño ; Ignacio Rojas ; Francisco Ortuño ; Fernando Rojas. Springer Verlag, 2019. pp. 477-485 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).

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Tagore, S & Frenkel-Morgenstern, M 2019, When Mathematics Outsmarts Cancer. in O Valenzuela, F Ortuño, I Rojas, F Ortuño & F Rojas (eds), Bioinformatics and Biomedical Engineering - 7th International Work-Conference, IWBBIO 2019, Proceedings. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 11465 LNBI, Springer Verlag, pp. 477-485, 7th International Work-Conference on Bioinformatics and Biomedical Engineering, IWBBIO 2019, Granada, Spain, 8/05/19. https://doi.org/10.1007/978-3-030-17938-0_42

When Mathematics Outsmarts Cancer. / Tagore, Somnath; Frenkel-Morgenstern, Milana.
Bioinformatics and Biomedical Engineering - 7th International Work-Conference, IWBBIO 2019, Proceedings. ed. / Olga Valenzuela; Francisco Ortuño; Ignacio Rojas; Francisco Ortuño; Fernando Rojas. Springer Verlag, 2019. p. 477-485 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 11465 LNBI).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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Tagore S, Frenkel-Morgenstern M. When Mathematics Outsmarts Cancer. In Valenzuela O, Ortuño F, Rojas I, Ortuño F, Rojas F, editors, Bioinformatics and Biomedical Engineering - 7th International Work-Conference, IWBBIO 2019, Proceedings. Springer Verlag. 2019. p. 477-485. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). doi: 10.1007/978-3-030-17938-0_42

When Mathematics Outsmarts Cancer

Abstract

Publication series

Conference

Bibliographical note

Keywords

UN SDGs

Access to Document

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Cite this