West Nile fever outbreak, Israel, 2000: Epidemiologic aspects

Miriam Weinberger, Silvio D. Pitlik, Dan Gandacu, Ruth Lang, Faris Nassar, Debora Ben David, Ethan Rubinstein, Avi Izthaki, Joseph Mishal, Ruth Kitzes, Yardena Siegman-Igra, Michael Giladi, Neora Pick, Ella Mendelson, Hanna Bin, Tamar Shohat, Michal Y. Chowers

Research output: Contribution to journalArticlepeer-review

166 Scopus citations


From August 1 to October 31, 2000, 417 cases of West Nile (WN) fever were serologically confirmed throughout Israel; 326 (78%) were hospitalized patients. Cases were distributed throughout the country; the highest incidence was in central Israel, the most populated part. Men and women were equally affected, and their mean age was 54±23.8 years (range 6 months to 95 years). Incidence per 1,000 population increased from 0.01 in the 1st decade of life to 0.87 in the 9th decade. There were 35 deaths (case-fatality rate 8.4%), all in patients >50 years of age. Age-specific case-fatality rate increased with age. Central nervous system involvement occurred in 170 (73%) of 233 hospitalized patients. The countrywide spread, number of hospitalizations, severity of the disease, and high death rate contrast with previously reported outbreaks in Israel.

Original languageEnglish
Pages (from-to)686-691
Number of pages6
JournalEmerging Infectious Diseases
Issue number4
StatePublished - 2001
Externally publishedYes


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