Weight gain and maternal behavior in CCK1 deficient rats

Mariana Schroeder; Orna Zagoory-Sharon; Yael Lavi-Avnon; Timothy H. Moran; Aron Weller

doi:10.1016/j.physbeh.2006.07.008

Weight gain and maternal behavior in CCK₁ deficient rats

Mariana Schroeder, Orna Zagoory-Sharon, Yael Lavi-Avnon, Timothy H. Moran, Aron Weller

Johns Hopkins University

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The OLETF rat model of obesity has been extensively studied as an adult model of hyperphagia-induced obesity. In order to better understand the early circumstances that make OLETF pups obese, we investigated body weight from postnatal day (PND) 1 and examined diurnal maternal behavior over the first three postpartum weeks by undisturbed observations. Male and female OLETF rats weighed significantly more than LETO controls from PND 1 until adulthood. Differences in nursing behavior were observed only in the third postnatal week: OLETF dams exhibited more frequent nursing. OLETF dams displayed less self-directed behaviors and activity, over the entire postpartum period examined. Taken together, these data demonstrate that OLETF males and females are heavier from birth and suggest that maternal factors may contribute to weight differences between the strains.

Original language	English
Pages (from-to)	402-409
Number of pages	8
Journal	Physiology and Behavior
Volume	89
Issue number	3
DOIs	https://doi.org/10.1016/j.physbeh.2006.07.008
State	Published - 30 Oct 2006

Bibliographical note

Funding Information:
The authors thank Dr. Kawano of Otsuka Tokushima Research Institute for the OLETF and LETO rats. OZS was partially supported by the Gonda Brain Research Center, Bar-Ilan University. This work was supported by a grant from the US–Israel Binational Research Foundation to AW and THM. Research in the Developmental Psychobiology lab is partially supported by the Paula Rich Center, Bar-Ilan University.

Funding

The authors thank Dr. Kawano of Otsuka Tokushima Research Institute for the OLETF and LETO rats. OZS was partially supported by the Gonda Brain Research Center, Bar-Ilan University. This work was supported by a grant from the US–Israel Binational Research Foundation to AW and THM. Research in the Developmental Psychobiology lab is partially supported by the Paula Rich Center, Bar-Ilan University.

Funders	Funder number
Gonda Brain Research Center
Paula Rich Center
US-Israel Binational Research Foundation
Bar-Ilan University

Keywords

CCK
Maternal care
Nursing
Obesity
Ontogeny
Weight gain

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.physbeh.2006.07.008

Cite this

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title = "Weight gain and maternal behavior in CCK1 deficient rats",

abstract = "The OLETF rat model of obesity has been extensively studied as an adult model of hyperphagia-induced obesity. In order to better understand the early circumstances that make OLETF pups obese, we investigated body weight from postnatal day (PND) 1 and examined diurnal maternal behavior over the first three postpartum weeks by undisturbed observations. Male and female OLETF rats weighed significantly more than LETO controls from PND 1 until adulthood. Differences in nursing behavior were observed only in the third postnatal week: OLETF dams exhibited more frequent nursing. OLETF dams displayed less self-directed behaviors and activity, over the entire postpartum period examined. Taken together, these data demonstrate that OLETF males and females are heavier from birth and suggest that maternal factors may contribute to weight differences between the strains.",

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note = "Funding Information: The authors thank Dr. Kawano of Otsuka Tokushima Research Institute for the OLETF and LETO rats. OZS was partially supported by the Gonda Brain Research Center, Bar-Ilan University. This work was supported by a grant from the US–Israel Binational Research Foundation to AW and THM. Research in the Developmental Psychobiology lab is partially supported by the Paula Rich Center, Bar-Ilan University. ",

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