Abstract
Several acid addition salts of amino ester derivatives of 3‐oxy‐substituted 1,4‐benzodiazepines were prepared and tested for water solubility, stability, and pH. The monomethanesulfonic acid salts were the most suitable for parenteral administration.
| Original language | English |
|---|---|
| Pages (from-to) | 1880-1885 |
| Number of pages | 6 |
| Journal | Journal of Pharmaceutical Sciences |
| Volume | 63 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 1974 |
| Externally published | Yes |
Keywords
- 1,4‐Benzodiazepines, 3‐oxy‐substituted—water‐soluble derivatives synthesized and tested for water solubility, stability, and pH
- Acid salts—synthesis of water‐soluble derivatives of 3‐oxy‐substituted 1,4‐benzodiazepines, tested for water solubility, stability, and pH
- Lorazepam—synthesis of aminoacetyl derivatives, tested for water solubility, stability, and pH
- Oxazepam—synthesis of aminoacetyl derivatives, tested for water solubility, stability, and pH