Vulvar vestibulitis: A familial occurrence?

J. Bornstein, Y. Ben-David, L. Hornstein, H. Abramovici

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


In two sisters with severe dyspareunia, human papillomavirus (HPV) associated vulvar vestibulitis was diagnosed. One patient was treated by intramuscular injections of interferon-beta to a total dose of 45 million international units. The other by perineoplasty. The bioptic/surgical specimens revealed koilocytotic changes in the former and HPV-DNA (by dot blot hybridization) in the latter. Both patients resulted to be cured by therapies. The possibility of a familial occurrence of vestibulitis is discussed in addition to other pathogenetic hypotheses.

Original languageEnglish
Pages (from-to)167-169
Number of pages3
JournalCervix and the Lower Female Genital Tract
Issue number3
StatePublished - 1992
Externally publishedYes


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