Vitamin E status among bariatric surgery patients: a systematic review

Shiri Sherf-Dagan, Assaf Buch, Tair Ben-Porat, Nasser Sakran, Tali Sinai

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Vitamin E, a fat-soluble vitamin with antioxidant properties, is thought to modulate enzymes involved in signal transduction, affect gene expression, and have immunomodulatory capabilities. Severe vitamin E deficiency is associated with neuronal disorders, impaired immune response, hemolytic anemia, and oxidative-based disorders. Patients who undergo bariatric surgery (BS), especially malabsorptive procedures, are at greater risk of developing fat-soluble vitamin deficiencies. Current data on vitamin E statuses among BS patients are limited. Therefore, this systematic review has summarized the scientific literature on vitamin E and examined its status among patients following different types of BS. Searches of the MEDLINE and Embase databases were performed, followed by hand-searching of reference lists from all relevant papers. Of the 671 initially identified articles, 24 met the inclusion criteria: 1 study on adjustable gastric banding patients (n = 21), 4 studies on sleeve gastrectomy patients (n = 173), 12 studies on Roux-en-Y gastric bypass patients (n = 689) and 12 studies on biliopancreatic diversion with or without duodenal switch (n = 799) or single anastomosis duodeno-ileal bypass with sleeve gastrectomy patients (n = 163). Results suggest that patients who undergo malabsorptive procedures are at higher risk of developing vitamin E deficiency, although clinical manifestations of vitamin E deficits following BS are rarely documented. The optimal dose of vitamin E supplementation required for prevention of deficiency or for treatment following BS has yet to be established. Future observational and intervention studies are needed to bridge the gaps in existing knowledge.

Original languageEnglish
Pages (from-to)816-830
Number of pages15
JournalSurgery for Obesity and Related Diseases
Issue number4
StatePublished - Apr 2021
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2020 American Society for Bariatric Surgery


  • Bariatric surgery
  • Nutritional deficiencies
  • Vitamin E
  • α-Tocopherol


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