Visualizing Nuclear RNA Editing

Hodaya Hochberg; Yaron Shav-Tal

doi:10.1016/j.tibs.2017.09.004

Visualizing Nuclear RNA Editing

Hodaya Hochberg, Yaron Shav-Tal

The Mina and Everard Goodman Faculty of Life Sciences

Research output: Contribution to journal › Short survey › peer-review

Abstract

RNA editing results in the site-specific conversion of adenosine to inosine in mRNAs. Genomics has revealed millions of editing sites in metazoans, but examining the spatial aspects of editing in cells has been challenging. A new method, inosineFISH (inoFISH), provides the ability to detect edited and unedited mRNAs within intact cells.

Original language	English
Pages (from-to)	845-847
Number of pages	3
Journal	Trends in Biochemical Sciences
Volume	42
Issue number	11
DOIs	https://doi.org/10.1016/j.tibs.2017.09.004
State	Published - Nov 2017

Bibliographical note

Funding Information:
The work in the Shav-Tal laboratory is supported by the Israel Science Foundation (ISF) and the US-Israel Binational Science Foundation (BSF).

Publisher Copyright:
© 2017 Elsevier Ltd

Keywords

RNA FISH
RNA editing
nuclear retention
paraspeckles

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10.1016/j.tibs.2017.09.004

Cite this

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Visualizing Nuclear RNA Editing

Abstract

Bibliographical note

Keywords

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