RNA editing results in the site-specific conversion of adenosine to inosine in mRNAs. Genomics has revealed millions of editing sites in metazoans, but examining the spatial aspects of editing in cells has been challenging. A new method, inosineFISH (inoFISH), provides the ability to detect edited and unedited mRNAs within intact cells.
Bibliographical noteFunding Information:
The work in the Shav-Tal laboratory is supported by the Israel Science Foundation (ISF) and the US-Israel Binational Science Foundation (BSF).
© 2017 Elsevier Ltd
- RNA FISH
- RNA editing
- nuclear retention