A versatile water-soluble chelating and radical scavenging platform

Meital Eckshtain-Levi; Ronit Lavi; Dmitry S. Yufit; Bareket Daniel; Omer Green; Ohad Fleker; Michal Richman; Shai Rahimipour; Arie Gruzman; Laurent Benisvy

doi:10.1039/c5cc08198j

A versatile water-soluble chelating and radical scavenging platform

Meital Eckshtain-Levi
, Ronit Lavi
, Dmitry S. Yufit
, Bareket Daniel
, Omer Green
, Ohad Fleker
, Michal Richman
, Shai Rahimipour
, Arie Gruzman
, Laurent Benisvy

Durham University
Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The phenol-diamide compound, 5-(tert-butyl)-2-hydroxy-N1,N3-bis(2-hydroxyethyl)isophthalamide (1OH), is water-soluble, non-cytotoxic, and capable of both, trapping ROS species and chelating Cu(ii) and Fe(iii) ions; these combined properties confer a protective effect against ROS induced cell death.

Original language	English
Pages (from-to)	2350-2353
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	11
DOIs	https://doi.org/10.1039/c5cc08198j
State	Published - 7 Feb 2016

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Publisher Copyright:
© The Royal Society of Chemistry 2016.

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abstract = "The phenol-diamide compound, 5-(tert-butyl)-2-hydroxy-N1,N3-bis(2-hydroxyethyl)isophthalamide (1OH), is water-soluble, non-cytotoxic, and capable of both, trapping ROS species and chelating Cu(ii) and Fe(iii) ions; these combined properties confer a protective effect against ROS induced cell death.",

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AU - Eckshtain-Levi, Meital

AU - Lavi, Ronit

AU - Yufit, Dmitry S.

AU - Daniel, Bareket

AU - Green, Omer

AU - Fleker, Ohad

AU - Richman, Michal

AU - Rahimipour, Shai

AU - Gruzman, Arie

AU - Benisvy, Laurent

PY - 2016/2/7

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N2 - The phenol-diamide compound, 5-(tert-butyl)-2-hydroxy-N1,N3-bis(2-hydroxyethyl)isophthalamide (1OH), is water-soluble, non-cytotoxic, and capable of both, trapping ROS species and chelating Cu(ii) and Fe(iii) ions; these combined properties confer a protective effect against ROS induced cell death.

AB - The phenol-diamide compound, 5-(tert-butyl)-2-hydroxy-N1,N3-bis(2-hydroxyethyl)isophthalamide (1OH), is water-soluble, non-cytotoxic, and capable of both, trapping ROS species and chelating Cu(ii) and Fe(iii) ions; these combined properties confer a protective effect against ROS induced cell death.

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JO - Chemical Communications

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A versatile water-soluble chelating and radical scavenging platform

Abstract

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