Verapamil in ventricular tachycardia

Y. Hasin, M. Kriwisky, M. S. Gotsman

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


We compared the effects of verapamil to high dose procainamide on the rate of inducible and spontaneously occurring ventricular tachycardia (VT) in 10 patients. Verapamil induced a significant increase in the rate of tachyardia (R-R interval decreased from 278 ± 54 to 233 ± 32 ms, mean ± SD; p <0.025 by paired t test) while procainamide slowed the tachycardia (mean R-R interval was 328 ± 72 ms, p <0.02). Verapamil prevented the induction of sustained VT and was effective as chronic oral antiarrhythmic therapy in 2 patients. The accelerated VT culminated in ventricular fibrillation in 1 patient. It is assumed that verapamil may have either increased conduction velocity or shortened the reentrant cycle. This may be related either to a primary effect of the drug or secondary to increased catecholamine stimulation due to a vasodilatory effect.

Original languageEnglish
Pages (from-to)199-206
Number of pages8
Issue number4
StatePublished - 1984
Externally publishedYes


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