TY - JOUR
T1 - Venous thromboembolism in patients with glioblastoma multiforme
T2 - Findings of the RIETE registry
AU - the RIETE Investigations
AU - Portillo, Jose
AU - De La Rocha, Iris Violeta
AU - Font, Llorenç
AU - Braester, Andrei
AU - Madridano, Olga
AU - Peromingo, José Antonio Díaz
AU - Apollonio, Alessandro
AU - Pagán, Barbara
AU - Bascuñana, José
AU - Monreal, Manuel
N1 - Publisher Copyright:
© 2015 Elsevier Ltd. All rights reserved.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Background There is uncertainty about the optimal therapy of venous thromboembolism (VTE) in patients with glioblastoma multiforme (GBM). Methods We used the RIETE (Registro Informatizado Enfermedad TromboEmbólica) database to compare the rate of VTE recurrences and major bleeding during the course of anticoagulation in patients with GBM, other cancers and in patients without cancer. Results As of September 2014, 53,546 patients have been recruited in RIETE. Of these, 72 (0.13%) had GBM and 11,811 (22%) had other cancers. Most patients in all 3 subgroups received initial therapy with low-molecular-weight heparin (LMWH), but those with GBM received slightly lower doses than those with other cancers or without cancer. Then, most patients with GBM continued on LMWH for long-term therapy, at similar doses than those in the other subgroups. During the course of anticoagulation (mean, 202 days), 3 patients with GBM presented VTE recurrences (10.9 per 100 patient-years; 95% CI: 2.76-29.5) and 4 suffered major bleeding (one intracranial) (14.5 bleeds per 100 patient-years; 95%CI: 4.60-34.9). Compared with patients with other cancers, those with GBM had a similar rate of VTE recurrences and major bleeds, but had a higher rate of extracranial hematoma (p < 0.05). Compared with VTE patients without cancer, those with GBM had a higher rate of PE recurrences (p < 0.01) and major bleeding (p < 0.001), particularly extracranial hematoma (p < 0.001). Conclusions Patients with GBM and VTE had a similar rate of VTE recurrences or major bleeds during the course of anticoagulant therapy than those with other cancers.
AB - Background There is uncertainty about the optimal therapy of venous thromboembolism (VTE) in patients with glioblastoma multiforme (GBM). Methods We used the RIETE (Registro Informatizado Enfermedad TromboEmbólica) database to compare the rate of VTE recurrences and major bleeding during the course of anticoagulation in patients with GBM, other cancers and in patients without cancer. Results As of September 2014, 53,546 patients have been recruited in RIETE. Of these, 72 (0.13%) had GBM and 11,811 (22%) had other cancers. Most patients in all 3 subgroups received initial therapy with low-molecular-weight heparin (LMWH), but those with GBM received slightly lower doses than those with other cancers or without cancer. Then, most patients with GBM continued on LMWH for long-term therapy, at similar doses than those in the other subgroups. During the course of anticoagulation (mean, 202 days), 3 patients with GBM presented VTE recurrences (10.9 per 100 patient-years; 95% CI: 2.76-29.5) and 4 suffered major bleeding (one intracranial) (14.5 bleeds per 100 patient-years; 95%CI: 4.60-34.9). Compared with patients with other cancers, those with GBM had a similar rate of VTE recurrences and major bleeds, but had a higher rate of extracranial hematoma (p < 0.05). Compared with VTE patients without cancer, those with GBM had a higher rate of PE recurrences (p < 0.01) and major bleeding (p < 0.001), particularly extracranial hematoma (p < 0.001). Conclusions Patients with GBM and VTE had a similar rate of VTE recurrences or major bleeds during the course of anticoagulant therapy than those with other cancers.
KW - Anticoagulant therapy
KW - Bleeding
KW - Glioblastoma
KW - Recurrences
KW - Venous thromboembolism
UR - http://www.scopus.com/inward/record.url?scp=84949309508&partnerID=8YFLogxK
U2 - 10.1016/j.thromres.2015.10.043
DO - 10.1016/j.thromres.2015.10.043
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C2 - 26548619
AN - SCOPUS:84949309508
SN - 0049-3848
VL - 136
SP - 1199
EP - 1203
JO - Thrombosis Research
JF - Thrombosis Research
IS - 6
ER -