Vasopressin signaling in kidney cells

D. A. Ausiello, K. L. Skorecki, A. S. Verkman, J. V. Bonventre

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

The two most well-studied secondary messenger systems in hormone physiology are cyclic adenosine monophosphate (cAMP) and calcium. In this present chapter we will describe the biochemical mechanisms in which vasopressin interacts with its V1 and V2 receptors generating, in specific cells, cAMP and/or calcium as second messengers. We will focus on two cell culture models that have been utilized to identify vasopressin signaling: the LLC-PK1 cell which contains the V2 receptor and the glomerular mesangial cell which contains the V1 receptor.

Original languageEnglish
Pages (from-to)521-529
Number of pages9
JournalKidney International
Volume31
Issue number2
DOIs
StatePublished - Feb 1987
Externally publishedYes

Bibliographical note

Funding Information:
Acknowledgments We acknowledge the editoral and secretarial assistance of Joan Carrick. This work was supported by USPHS Grants AM-19406, AM-35124, and HL-31513, Ontario Heart Foundation Grant AN 106, and a Kidney Foundation of Canada grant. K.L. Skorecki is a scholar of the Canadian Heart Foundation.

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