Vasopressin signaling in kidney cells

D. A. Ausiello; K. L. Skorecki; A. S. Verkman; J. V. Bonventre

doi:10.1038/ki.1987.31

Vasopressin signaling in kidney cells

D. A. Ausiello, K. L. Skorecki, A. S. Verkman, J. V. Bonventre

Massachusetts General Hospital

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

The two most well-studied secondary messenger systems in hormone physiology are cyclic adenosine monophosphate (cAMP) and calcium. In this present chapter we will describe the biochemical mechanisms in which vasopressin interacts with its V1 and V2 receptors generating, in specific cells, cAMP and/or calcium as second messengers. We will focus on two cell culture models that have been utilized to identify vasopressin signaling: the LLC-PK₁ cell which contains the V2 receptor and the glomerular mesangial cell which contains the V1 receptor.

Original language	English
Pages (from-to)	521-529
Number of pages	9
Journal	Kidney International
Volume	31
Issue number	2
DOIs	https://doi.org/10.1038/ki.1987.31
State	Published - Feb 1987
Externally published	Yes

Bibliographical note

Funding Information:
Acknowledgments We acknowledge the editoral and secretarial assistance of Joan Carrick. This work was supported by USPHS Grants AM-19406, AM-35124, and HL-31513, Ontario Heart Foundation Grant AN 106, and a Kidney Foundation of Canada grant. K.L. Skorecki is a scholar of the Canadian Heart Foundation.

Funding

Acknowledgments We acknowledge the editoral and secretarial assistance of Joan Carrick. This work was supported by USPHS Grants AM-19406, AM-35124, and HL-31513, Ontario Heart Foundation Grant AN 106, and a Kidney Foundation of Canada grant. K.L. Skorecki is a scholar of the Canadian Heart Foundation.

Funders	Funder number
Ontario Heart Foundation	AN 106
National Heart, Lung, and Blood Institute	R01HL031513
U.S. Public Health Service	AM-19406, AM-35124
Kidney Foundation of Canada

Access to Document

10.1038/ki.1987.31

Cite this

@article{62053734de7d453a8962368640535466,

title = "Vasopressin signaling in kidney cells",

abstract = "The two most well-studied secondary messenger systems in hormone physiology are cyclic adenosine monophosphate (cAMP) and calcium. In this present chapter we will describe the biochemical mechanisms in which vasopressin interacts with its V1 and V2 receptors generating, in specific cells, cAMP and/or calcium as second messengers. We will focus on two cell culture models that have been utilized to identify vasopressin signaling: the LLC-PK1 cell which contains the V2 receptor and the glomerular mesangial cell which contains the V1 receptor.",

author = "Ausiello, {D. A.} and Skorecki, {K. L.} and Verkman, {A. S.} and Bonventre, {J. V.}",

note = "Funding Information: Acknowledgments We acknowledge the editoral and secretarial assistance of Joan Carrick. This work was supported by USPHS Grants AM-19406, AM-35124, and HL-31513, Ontario Heart Foundation Grant AN 106, and a Kidney Foundation of Canada grant. K.L. Skorecki is a scholar of the Canadian Heart Foundation.",

year = "1987",

month = feb,

doi = "10.1038/ki.1987.31",

language = "אנגלית",

volume = "31",

pages = "521--529",

journal = "Kidney International",

issn = "0085-2538",

publisher = "Elsevier B.V.",

number = "2",

}

TY - JOUR

T1 - Vasopressin signaling in kidney cells

AU - Ausiello, D. A.

AU - Skorecki, K. L.

AU - Verkman, A. S.

AU - Bonventre, J. V.

N1 - Funding Information: Acknowledgments We acknowledge the editoral and secretarial assistance of Joan Carrick. This work was supported by USPHS Grants AM-19406, AM-35124, and HL-31513, Ontario Heart Foundation Grant AN 106, and a Kidney Foundation of Canada grant. K.L. Skorecki is a scholar of the Canadian Heart Foundation.

PY - 1987/2

Y1 - 1987/2

N2 - The two most well-studied secondary messenger systems in hormone physiology are cyclic adenosine monophosphate (cAMP) and calcium. In this present chapter we will describe the biochemical mechanisms in which vasopressin interacts with its V1 and V2 receptors generating, in specific cells, cAMP and/or calcium as second messengers. We will focus on two cell culture models that have been utilized to identify vasopressin signaling: the LLC-PK1 cell which contains the V2 receptor and the glomerular mesangial cell which contains the V1 receptor.

AB - The two most well-studied secondary messenger systems in hormone physiology are cyclic adenosine monophosphate (cAMP) and calcium. In this present chapter we will describe the biochemical mechanisms in which vasopressin interacts with its V1 and V2 receptors generating, in specific cells, cAMP and/or calcium as second messengers. We will focus on two cell culture models that have been utilized to identify vasopressin signaling: the LLC-PK1 cell which contains the V2 receptor and the glomerular mesangial cell which contains the V1 receptor.

UR - http://www.scopus.com/inward/record.url?scp=0023155760&partnerID=8YFLogxK

U2 - 10.1038/ki.1987.31

DO - 10.1038/ki.1987.31

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 2951552

AN - SCOPUS:0023155760

SN - 0085-2538

VL - 31

SP - 521

EP - 529

JO - Kidney International

JF - Kidney International

IS - 2

ER -

Vasopressin signaling in kidney cells

Abstract

Bibliographical note

Funding

Access to Document

Other files and links

Fingerprint

Cite this