TY - JOUR
T1 - Vasoconstriction by Electrical Stimulation: New Approach to Control of Non-Compressible Hemorrhage.,
AU - Mandel, Yossi
AU - Manivanh, Richard
AU - Dalal, Roopa
AU - Huie, Phil
AU - Wang, Jenny
AU - Brinton, Mark
AU - Palanker, Daniel
PY - 2013
Y1 - 2013
N2 - Non-compressible hemorrhage is the most common preventable cause of death on battlefield and in civilian traumatic injuries. We report the use of microsecond pulses of electric current to induce rapid constriction in femoral and mesenteric arteries and veins in rats. Electrically-induced vasoconstriction could be induced in seconds while blood vessels dilated back to their original size within minutes after stimulation. At higher settings, a blood clotting formed, leading to complete and permanent occlusion of the vessels. The latter regime dramatically decreased the bleeding rate in the injured femoral and mesenteric arteries, with a complete hemorrhage arrest achieved within seconds. The average blood loss from the treated femoral artery during the first minute after injury was about 7 times less than that of a non-treated control. This new treatment modality offers a promising approach to non-damaging control of bleeding during surgery, and to efficient hemorrhage arrest in trauma patients.,
AB - Non-compressible hemorrhage is the most common preventable cause of death on battlefield and in civilian traumatic injuries. We report the use of microsecond pulses of electric current to induce rapid constriction in femoral and mesenteric arteries and veins in rats. Electrically-induced vasoconstriction could be induced in seconds while blood vessels dilated back to their original size within minutes after stimulation. At higher settings, a blood clotting formed, leading to complete and permanent occlusion of the vessels. The latter regime dramatically decreased the bleeding rate in the injured femoral and mesenteric arteries, with a complete hemorrhage arrest achieved within seconds. The average blood loss from the treated femoral artery during the first minute after injury was about 7 times less than that of a non-treated control. This new treatment modality offers a promising approach to non-damaging control of bleeding during surgery, and to efficient hemorrhage arrest in trauma patients.,
UR - http://www.ncbi.nlm.nih.gov/pubmed/23828130,
UR - http://scholar.google.com/scholar?num=3&hl=en&lr=&q=allintitle%3A%20Vasoconstriction%20by%20Electrical%20Stimulation%3A%20New%20Approach%20to%20Control%20of%20Non-Compressible%20Hemorrhage.%2C%20author%3AYossi%20OR%20author%3AMandel%20OR%20author%3ARichard%20OR%20author%3AManivanh%20OR%20author%3ARoopa%20OR%20author%3ADalal%20OR%20author%3APhil%20OR%20author%3AHuie%20OR%20author%3AJenny%20OR%20author%3AWang%20OR%20author%3AMark%20OR%20author%3ABrinton%20OR%20author%3ADaniel%20OR%20author%3APalanker&as_ylo=2013&as_yhi=&btnG=Search&as_vis=0
M3 - Article
VL - 3
SP - 2111
JO - Scientific Reports,
JF - Scientific Reports,
ER -