TY - JOUR
T1 - Value of cardiophrenic angle lymph node for the diagnosis of colorectal peritoneal carcinomatosis
AU - Caramella, C.
AU - Pottier, E.
AU - Borget, I.
AU - Malka, D.
AU - Goéré, D.
AU - Boige, V.
AU - Honoré, C.
AU - Dartigues, P.
AU - Dumont, F.
AU - Ducreux, M.
AU - Elias, D.
AU - Dromain, C.
PY - 2013/12
Y1 - 2013/12
N2 - Background Cardiophrenic angle lymph nodes (CPALN) have been reported in patients with abdominopelvic malignancies. We aimed to assess whether the presence of CPALN is associated with peritoneal carcinomatosis (PC) in colorectal cancer. Patients and methods Between 2007 and 2011, 550 patients with colorectal cancer, including 165 (30%) with PC, had undergone surgery with complete peritoneal exploration. We retrospectively reviewed preoperative CT scans for the presence of CPALN and assessed its association with confirmed PC by univariate and multivariate analyses. Results CPALN were present in 123 (75%) patients with PC, but absent in 263 (68%) patients without PC (Se: 0.72; Sp: 0.68; PPV: 0.49; NPV: 0.85; [OR], 3.3; p < 0.001). PC was the only factor independently associated with CPALN in the multivariate analysis. CPALN was not correlated with the presence of liver metastases. 99 of the 165 patients with PC (62%) had visible signs of PC on CT scan. Among the remaining 66 patients, CPALN were the only potential sign of PC in 41 (62%), (Se 0.62, Sp 0.68, PPV 0.24, and NPV 0.92). Conclusion The detection of CPALN on CT may be of valuable help for the diagnosis of PC in patients with CRC.
AB - Background Cardiophrenic angle lymph nodes (CPALN) have been reported in patients with abdominopelvic malignancies. We aimed to assess whether the presence of CPALN is associated with peritoneal carcinomatosis (PC) in colorectal cancer. Patients and methods Between 2007 and 2011, 550 patients with colorectal cancer, including 165 (30%) with PC, had undergone surgery with complete peritoneal exploration. We retrospectively reviewed preoperative CT scans for the presence of CPALN and assessed its association with confirmed PC by univariate and multivariate analyses. Results CPALN were present in 123 (75%) patients with PC, but absent in 263 (68%) patients without PC (Se: 0.72; Sp: 0.68; PPV: 0.49; NPV: 0.85; [OR], 3.3; p < 0.001). PC was the only factor independently associated with CPALN in the multivariate analysis. CPALN was not correlated with the presence of liver metastases. 99 of the 165 patients with PC (62%) had visible signs of PC on CT scan. Among the remaining 66 patients, CPALN were the only potential sign of PC in 41 (62%), (Se 0.62, Sp 0.68, PPV 0.24, and NPV 0.92). Conclusion The detection of CPALN on CT may be of valuable help for the diagnosis of PC in patients with CRC.
KW - Colorectal cancer
KW - Early diagnosis
KW - Lymph nodes
KW - Peritoneal cavity
UR - http://www.scopus.com/inward/record.url?scp=84888012317&partnerID=8YFLogxK
U2 - 10.1016/j.ejca.2013.06.044
DO - 10.1016/j.ejca.2013.06.044
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C2 - 23899531
AN - SCOPUS:84888012317
SN - 0959-8049
VL - 49
SP - 3798
EP - 3805
JO - European Journal of Cancer
JF - European Journal of Cancer
IS - 18
ER -