TY - JOUR
T1 - Using psychiatric symptomatology to assess risk for HIV infection in individuals with severe mental illness
AU - Wu, Evan S.
AU - Rothbard, Aileen
AU - Blank, Michael B.
PY - 2011/12
Y1 - 2011/12
N2 - In this study, we use the Colorado Symptom Index, a measure of psychiatric symptomatology, to identify vulnerable subgroups within the severely mentally ill population at elevated risk for HIV infection. Baseline data on 228 HIV positive and 281 HIV negative participants from two clinical trials were used. With years to HIV diagnosis as our primary endpoint, Kaplan-Meier estimates were calculated to find a CSI cut-off score, and a Cox proportional hazards model was used to obtain relative risks of infection for the two CSI categories created by the cut point. We found that a CSI score ≥ 30 was associated with a 47% increased risk for HIV infection (P < 0.01). While this study establishes the foundation for using CSI scores to identify a vulnerable subgroup within the SMI community, further studies should develop effective approaches to mitigate psychiatric symptomatology in order to examine the impact on HIV transmission risky behaviors.
AB - In this study, we use the Colorado Symptom Index, a measure of psychiatric symptomatology, to identify vulnerable subgroups within the severely mentally ill population at elevated risk for HIV infection. Baseline data on 228 HIV positive and 281 HIV negative participants from two clinical trials were used. With years to HIV diagnosis as our primary endpoint, Kaplan-Meier estimates were calculated to find a CSI cut-off score, and a Cox proportional hazards model was used to obtain relative risks of infection for the two CSI categories created by the cut point. We found that a CSI score ≥ 30 was associated with a 47% increased risk for HIV infection (P < 0.01). While this study establishes the foundation for using CSI scores to identify a vulnerable subgroup within the SMI community, further studies should develop effective approaches to mitigate psychiatric symptomatology in order to examine the impact on HIV transmission risky behaviors.
KW - Colorado symptom index (CSI)
KW - HIV risk factors
KW - Psychiatric symptomatology
KW - Severe mental illness
UR - http://www.scopus.com/inward/record.url?scp=82655173662&partnerID=8YFLogxK
U2 - 10.1007/s10597-011-9402-0
DO - 10.1007/s10597-011-9402-0
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C2 - 21479681
AN - SCOPUS:82655173662
SN - 0010-3853
VL - 47
SP - 672
EP - 678
JO - Community Mental Health Journal
JF - Community Mental Health Journal
IS - 6
ER -