Use of inhaled corticosteroids for the prevention and/or treatment of bronchopulmonary dysplasia in preterm infants: A systematic review protocol

Eric S. Shinwell, Igor Portnov, Joerg Meerpohl, Tanja Karen, Dirk Bassler

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Background: Inhaled steroids have been studied for both prevention and treatment of bronchopulmonary dysplasia (BPD). Results have been inconsistent. Recently, a large randomized controlled trial (RCT) has been reported. Methods/design: We will perform a comprehensive systematic literature search for randomized and quasi-randomized controlled trials that studied the efficacy and safety of inhaled corticosteroids administered to preterm infants (22-36weeks) for either the prevention or treatment of BPD diagnosed by both clinical and physiological outcome criteria. We will assess potential risk of bias for each RCT meeting our selection criteria using the Cochrane risk of bias tool for RCTs. The primary outcome of interest will be mortality or BPD or both at 28days postnatal age or 36weeks postmenstrual age. Pooled estimates will be calculated using RevMan software with a random effects model as primary analysis. We will assess the quality of evidence using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Discussion: Meta-analytic estimates of eligible RCTs, potentially including a new large RCT, may significantly influence neonatal practice in the prevention and treatment of respiratory problems in preterm infants.

Original languageEnglish
Article number127
JournalSystematic Reviews
Volume4
Issue number1
DOIs
StatePublished - 25 Sep 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2015 Shinwell et al.

Keywords

  • Bronchopulmonary dysplasia
  • Corticosteroids
  • Inhaled corticosteroids
  • Preterm infant
  • Prevention

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