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Uridine Depletion and Chemical Modification Increase Cas9 mRNA Activity and Reduce Immunogenicity without HPLC Purification

  • Sriram Vaidyanathan
  • , Krist T. Azizian
  • , A. K.M.Ashiqul Haque
  • , Jordana M. Henderson
  • , Ayal Hendel
  • , Sabrina Shore
  • , Justin S. Antony
  • , Richard I. Hogrefe
  • , Michael S.D. Kormann
  • , Matthew H. Porteus
  • , Anton P. McCaffrey
  • Stanford University
  • TriLink BioTechnologies
  • University of Tübingen

Research output: Contribution to journal › Article › peer-review

250 Scopus citations

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Biochemistry, Genetics and Molecular Biology

Medicine and Dentistry

Immunology and Microbiology

Neuroscience