Ultrastructural changes in the ovaries of infant mice deprived of endogenous gonadotrophins and after substitution with FSH

B. Hardy, D. Danon, A. Eshkol, B. Lunenfeld

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Abstract

The ultrastructure of ovaries of infant mice deprived of gonadotropins was compared to the normal developmental pattern and to that of animals deprived of endogenous gonadotropins but receiving follicle stimulating hormone (FSH). In the absence of circulating gonadotropins, structural changes were observed; granulosa cell nuclei were irregularly shaped rather than round, and the spaces between the granulosa cells disappeared as did the spaces between the granulosa cells and the oocyte. The most striking effect was observed in the zona pellucida, the width of which diminished and became irregular. The number of cell processes within the zona pellucida was markedly reduced. These changes are tentatively attributed to alteration in the structure of the granulosa cell. Substitution with FSH partly prevented these changes, indicating that FSH plays a role in the preservation of the integrity of the granulosa cell membrane.

Original languageEnglish
Pages (from-to)345-352
Number of pages8
JournalJournal of Reproduction and Fertility
Volume36
Issue number2
DOIs
StatePublished - 1974
Externally publishedYes

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