TY - JOUR
T1 - Ultrastructural changes in the ovaries of infant mice deprived of endogenous gonadotrophins and after substitution with FSH
AU - Hardy, B.
AU - Danon, D.
AU - Eshkol, A.
AU - Lunenfeld, B.
PY - 1974
Y1 - 1974
N2 - The ultrastructure of ovaries of infant mice deprived of gonadotropins was compared to the normal developmental pattern and to that of animals deprived of endogenous gonadotropins but receiving follicle stimulating hormone (FSH). In the absence of circulating gonadotropins, structural changes were observed; granulosa cell nuclei were irregularly shaped rather than round, and the spaces between the granulosa cells disappeared as did the spaces between the granulosa cells and the oocyte. The most striking effect was observed in the zona pellucida, the width of which diminished and became irregular. The number of cell processes within the zona pellucida was markedly reduced. These changes are tentatively attributed to alteration in the structure of the granulosa cell. Substitution with FSH partly prevented these changes, indicating that FSH plays a role in the preservation of the integrity of the granulosa cell membrane.
AB - The ultrastructure of ovaries of infant mice deprived of gonadotropins was compared to the normal developmental pattern and to that of animals deprived of endogenous gonadotropins but receiving follicle stimulating hormone (FSH). In the absence of circulating gonadotropins, structural changes were observed; granulosa cell nuclei were irregularly shaped rather than round, and the spaces between the granulosa cells disappeared as did the spaces between the granulosa cells and the oocyte. The most striking effect was observed in the zona pellucida, the width of which diminished and became irregular. The number of cell processes within the zona pellucida was markedly reduced. These changes are tentatively attributed to alteration in the structure of the granulosa cell. Substitution with FSH partly prevented these changes, indicating that FSH plays a role in the preservation of the integrity of the granulosa cell membrane.
UR - http://www.scopus.com/inward/record.url?scp=0015980793&partnerID=8YFLogxK
U2 - 10.1530/jrf.0.0360345
DO - 10.1530/jrf.0.0360345
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C2 - 4819316
AN - SCOPUS:0015980793
SN - 0022-4251
VL - 36
SP - 345
EP - 352
JO - Journal of Reproduction and Fertility
JF - Journal of Reproduction and Fertility
IS - 2
ER -