Ultrasound technology assisted colloidal nanocrystal synthesis and biomedical applications

Haorong Jiao, Qiulian Mao, Noman Razzaq, Rinat Ankri, Jiabin Cui

Research output: Contribution to journalArticlepeer-review


Non-invasive and high spatiotemporal resolution mythologies for the diagnosis and treatment of disease in clinical medicine promote the development of modern medicine. Ultrasound (US) technology provides a non-invasive, real-time, and cost-effective clinical imaging modality, which plays a significant role in chemical synthesis and clinical translation, especially in in vivo imaging and cancer therapy. On the one hand, the US treatment is usually accompanied by cavitation, leading to high temperature and pressure, so-called “hot spot”, playing a significant role in sonochemical-based colloidal synthesis. Compared with the classical nucleation synthetic method, the sonochemical synthesis strategy presents high efficiency for the fabrication of colloidal nanocrystals due to its fast nucleation and growth procedure. On the other hand, the US is attractive for in vivo and medical treatment, with applications increasing with the development of novel contrast agents, such as the micro and nano bubbles, which are widely used in neuromodulation, with which the US can breach the blood–brain barrier temporarily and safely, opening a new door to neuromodulation and therapy. In terms of cancer treatment, sonodynamic therapy and US-assisted synergetic therapy show great effects against cancer and sonodynamic immunotherapy present unparalleled potentiality compared with other synergetic therapies. Further development of ultrasound technology can revolutionize both chemical synthesis and clinical translation by improving efficiency, precision, and accessibility while reducing environmental impact and enhancing patient care. In this paper, we review the US-assisted sonochemical synthesis and biological applications, to promote the next generation US technology-assisted applications.

Original languageEnglish
Article number106798
JournalUltrasonics Sonochemistry
Early online date6 Feb 2024
StatePublished - Feb 2024
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2024 The Author(s)


This work was supported by the National Natural Science Foundation of China (No. 22104105 ), the Natural Science Foundation of Jiangsu Province (No. BK20210702 ), Leading Talents of Innovation and Entrepreneurship of Gusu (No. ZXL2022515), Research Fund from Soochow University and the Council for higher education, Israel (No. RA2100000248 ).

FundersFunder number
Leading Talents of Innovation and Entrepreneurship of GusuZXL2022515
National Natural Science Foundation of China22104105
Natural Science Foundation of Jiangsu ProvinceBK20210702
Council for Higher EducationRA2100000248
Soochow University


    • Diagnosis and therapy
    • In vivo imaging
    • Sonochemical synthesis
    • US contrast agents
    • Ultrasound


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