Abstract
Psoriasis is a common, worldwide autoinflammatory, incurable skin disease. miR-197 has therapeutic potential for psoriasis since it can down-regulate the expression of both IL-22RA1 and IL-17RA, subunits of the receptors of IL-22 and IL-17, respectively, which are key cytokines in the disease. Although miR-197 has the potential to treat the disease, several inherent physical barrier properties of the skin challenge miRNA's delivery to the target skin cells. In the present study, we evaluated a therapeutic approach that combines the use of ultrasound (US) as a means to enhance skin permeability with quaternized starch (Q-starch) as an miRNA delivery carrier. This resulted in decreased expression of the miR-197 target proteins and in a significant reduction in the psoriatic activity markers. Our results demonstrate the potential of combinations of US and Q-starch/miR-197 complexes for the topical skin treatment of psoriasis.
Original language | English |
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Pages (from-to) | 103-111 |
Number of pages | 9 |
Journal | Journal of Controlled Release |
Volume | 284 |
DOIs | |
State | Published - 28 Aug 2018 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2018
Funding
The work was funded by Kamin ( Office of the Chief Scientist, Israel ) ( 51401 , 51402 to J. K. and Y.S. and D.A) and Israel Science Foundation (ISF) ( 722/15 ) to J.K and Israel Ministry of Health , research number 3-10132 to D.A and Y.S. The work was funded by Kamin (Office of the Chief Scientist, Israel) (51401, 51402 to J. K. and Y.S. and D.A) and Israel Science Foundation (ISF) (722/15) to J.K and Israel Ministry of Health, research number 3-10132 to D.A and Y.S.
Funders | Funder number |
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Israel Ministry of Health | 3-10132 |
Israel Science Foundation | 722/15 |
Ministry of Health | |
Office of the Chief Scientist, Ministry of Economy | 51401, 51402 |
Keywords
- Psoriasis
- Starch
- Topical gene delivery
- Transdermal
- Ultrasound
- miR-197