TY - JOUR
T1 - Ultrafine Highly Magnetic Fluorescent δ-Fe2O3/NCD Nanocomposites for Neuronal Manipulations
AU - Kumar, Vijay Bhooshan
AU - Marcus, Michal
AU - Porat, Ze'Ev
AU - Shani, Lior
AU - Yeshurun, Yosef
AU - Felner, Israel
AU - Shefi, Orit
AU - Gedanken, Aharon
N1 - Publisher Copyright:
© 2018 American Chemical Society.
PY - 2018/2/28
Y1 - 2018/2/28
N2 - In this work, we describe a low-cost, two-step synthesis of composites of nitrogen-doped carbon quantum dots (NCDs) with γ-Fe2O3 (NCDs/γ-Fe2O3), which is based on a hydrothermal cum co-precipitation method. The product is a fine powder of particles having an average diameter of 9 ± 3 nm. The physical and chemical properties of NCDs/γ-Fe2O3 were studied, as well as the superconducting quantum interference device and Mossbauer analysis of the magnetic properties of these nanocomposites. The interaction of NCDs/γ-Fe2O3 nanocomposites with neuron-like cells was examined, showing efficient uptake and low toxicity. Our research demonstrates the use of the nanocomposites for imaging and for controlling the cellular motility. The NCDs/γ-Fe2O3 nanocomposites are promising because of their biocompatibility, photostability, and potential selective affinity, paving the way for multifunctional biomedical applications.
AB - In this work, we describe a low-cost, two-step synthesis of composites of nitrogen-doped carbon quantum dots (NCDs) with γ-Fe2O3 (NCDs/γ-Fe2O3), which is based on a hydrothermal cum co-precipitation method. The product is a fine powder of particles having an average diameter of 9 ± 3 nm. The physical and chemical properties of NCDs/γ-Fe2O3 were studied, as well as the superconducting quantum interference device and Mossbauer analysis of the magnetic properties of these nanocomposites. The interaction of NCDs/γ-Fe2O3 nanocomposites with neuron-like cells was examined, showing efficient uptake and low toxicity. Our research demonstrates the use of the nanocomposites for imaging and for controlling the cellular motility. The NCDs/γ-Fe2O3 nanocomposites are promising because of their biocompatibility, photostability, and potential selective affinity, paving the way for multifunctional biomedical applications.
UR - http://www.scopus.com/inward/record.url?scp=85050393058&partnerID=8YFLogxK
U2 - 10.1021/acsomega.7b01666
DO - 10.1021/acsomega.7b01666
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C2 - 30023817
AN - SCOPUS:85050393058
SN - 2470-1343
VL - 3
SP - 1897
EP - 1903
JO - ACS Omega
JF - ACS Omega
IS - 2
ER -