Ultra-small natural product based coordination polymer nanodots for acute kidney injury relief

Rui Zhang, Liang Cheng, Ziliang Dong, Linqian Hou, Shaohua Zhang, Zhouqi Meng, Oshra Betzer, Yihua Wang, Rachela Popovtzer, Zhuang Liu

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Acute kidney injury (AKI) is frequently associated with reactive oxygen species (ROS) and causes high mortality in clinics annually, and nanotechnology-mediated antioxidative therapy is emerging as a novel strategy for AKI treatment. Herein, four kinds of natural antioxidants are able to coordinate with iron (Fe) ions to form ultra-small coordination polymer nanodots (CPNs) with good water dispersibility and strong ROS scavenging ability. In particular, Fe-curcumin CPNs (Fe-Cur CPNs) are applied for cellular ROS scavenging and rhabdomyolysis-induced AKI relief.

Original languageEnglish
Pages (from-to)1314-1322
Number of pages9
JournalMaterials Horizons
Volume8
Issue number4
DOIs
StatePublished - Apr 2021

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© The Royal Society of Chemistry.

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