Ultra-small natural product based coordination polymer nanodots for acute kidney injury relief

Rui Zhang; Liang Cheng; Ziliang Dong; Linqian Hou; Shaohua Zhang; Zhouqi Meng; Oshra Betzer; Yihua Wang; Rachela Popovtzer; Zhuang Liu

doi:10.1039/d0mh00193g

Ultra-small natural product based coordination polymer nanodots for acute kidney injury relief

Rui Zhang, Liang Cheng, Ziliang Dong, Linqian Hou, Shaohua Zhang, Zhouqi Meng, Oshra Betzer, Yihua Wang, Rachela Popovtzer, Zhuang Liu

Soochow University

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

Acute kidney injury (AKI) is frequently associated with reactive oxygen species (ROS) and causes high mortality in clinics annually, and nanotechnology-mediated antioxidative therapy is emerging as a novel strategy for AKI treatment. Herein, four kinds of natural antioxidants are able to coordinate with iron (Fe) ions to form ultra-small coordination polymer nanodots (CPNs) with good water dispersibility and strong ROS scavenging ability. In particular, Fe-curcumin CPNs (Fe-Cur CPNs) are applied for cellular ROS scavenging and rhabdomyolysis-induced AKI relief.

Original language	English
Pages (from-to)	1314-1322
Number of pages	9
Journal	Materials Horizons
Volume	8
Issue number	4
DOIs	https://doi.org/10.1039/d0mh00193g
State	Published - Apr 2021

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© The Royal Society of Chemistry.

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abstract = "Acute kidney injury (AKI) is frequently associated with reactive oxygen species (ROS) and causes high mortality in clinics annually, and nanotechnology-mediated antioxidative therapy is emerging as a novel strategy for AKI treatment. Herein, four kinds of natural antioxidants are able to coordinate with iron (Fe) ions to form ultra-small coordination polymer nanodots (CPNs) with good water dispersibility and strong ROS scavenging ability. In particular, Fe-curcumin CPNs (Fe-Cur CPNs) are applied for cellular ROS scavenging and rhabdomyolysis-induced AKI relief.",

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AU - Zhang, Rui

AU - Cheng, Liang

AU - Dong, Ziliang

AU - Hou, Linqian

AU - Zhang, Shaohua

AU - Meng, Zhouqi

AU - Betzer, Oshra

AU - Wang, Yihua

AU - Popovtzer, Rachela

AU - Liu, Zhuang

PY - 2021/4

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AB - Acute kidney injury (AKI) is frequently associated with reactive oxygen species (ROS) and causes high mortality in clinics annually, and nanotechnology-mediated antioxidative therapy is emerging as a novel strategy for AKI treatment. Herein, four kinds of natural antioxidants are able to coordinate with iron (Fe) ions to form ultra-small coordination polymer nanodots (CPNs) with good water dispersibility and strong ROS scavenging ability. In particular, Fe-curcumin CPNs (Fe-Cur CPNs) are applied for cellular ROS scavenging and rhabdomyolysis-induced AKI relief.

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Ultra-small natural product based coordination polymer nanodots for acute kidney injury relief

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