@inproceedings{ff93ca6d70fd432d89ddfbb7cd2945c0,
title = "Ultra high-throughput single molecule spectroscopy with a 1024 pixel SPAD",
abstract = "Single-molecule spectroscopy is a powerful approach to measuring molecular properties such as size, brightness, conformation, and binding constants. Due to the low concentrations in the single-molecule regime, measurements with good statistical accuracy require long acquisition times. Previously we showed a factor of 8 improvement in acquisition speed using a custom-CMOS 8x1 SPAD array. Here we present preliminary results with a 64X improvement in throughput obtained using a liquid crystal on silicon spatial light modulator (LCOS-SLM) and a novel standard CMOS 1024 pixel SPAD array, opening the way to truly high-throughput single-molecule spectroscopy.",
keywords = "CMOS, FCS, LCOS, SPAD array, fluorescence, high-throughput, photon counting, single-molecule",
author = "Colyer, {Ryan A.} and Giuseppe Scalia and Villa, {Federica A.} and Fabrizio Guerrieri and Simone Tisa and Franco Zappa and Sergio Cova and Shimon Weiss and Xavier Michalet",
year = "2011",
doi = "10.1117/12.874238",
language = "אנגלית",
isbn = "9780819484420",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Single Molecule Spectroscopy and Imaging IV",
note = "Single Molecule Spectroscopy and Imaging IV ; Conference date: 22-01-2011 Through 23-01-2011",
}