Ubiquitylation-dependent downregulation of Nck regulates its functional activity

Noah Joseph, Barak Reicher, Ahuvit David, Omri Matalon, Mira Barda-Saad

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The Nck adapter protein is involved in key cellular functions, such as actin polymerization and reorganization, serving as a molecular bridge between the surface complex essential for foreign antigen recognition, the T-cell antigen receptor (TCR), and the actin machinery. However, the mechanisms regulating Nck expression and functions are unknown. In this study, we revealed Nck negative regulation and demonstrated that Nck is ubiquitylated following cellular activation. We identified the molecular determinants and mediators involved in this process. Our data suggest that Nck ubiquitylation might serve as a mechanism controlling Nck-mediated effector functions during cellular activation.

Original languageEnglish
Pages (from-to)3808-3815
Number of pages8
JournalFEBS Letters
Issue number21
StatePublished - 3 Nov 2014

Bibliographical note

Publisher Copyright:
© 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.


  • Actin machinery
  • Nck
  • T-cell signaling
  • Ubiquitylation


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