TY - JOUR
T1 - Two-Stage Inversion-Recovery Experiments for Measurements of T1
AU - Taitelbaum, Haim
AU - Ferretti, James A.
AU - Spencer, Richard G.S.
AU - Weiss, George H.
PY - 1993
Y1 - 1993
N2 - A theory for the optimal design of experiments for measuring values of T1 using a two-stage design is developed. It is shown that a useful strategy in such designs is to make a preliminary rough estimate of T1 and use the second stage to produce a refinement of the preliminary results. When the initial uncertainty interval for T1 is large, the two-stage design produces results much less sensitive to the value of the true T1 than those obtainable from a single-stage design. This leads to a significant improvement in the precision of estimates of T1, and in circumstances that depend on the value of T1 estimated in the first stage of the experiment, to a considerable saving in spectrometer time.
AB - A theory for the optimal design of experiments for measuring values of T1 using a two-stage design is developed. It is shown that a useful strategy in such designs is to make a preliminary rough estimate of T1 and use the second stage to produce a refinement of the preliminary results. When the initial uncertainty interval for T1 is large, the two-stage design produces results much less sensitive to the value of the true T1 than those obtainable from a single-stage design. This leads to a significant improvement in the precision of estimates of T1, and in circumstances that depend on the value of T1 estimated in the first stage of the experiment, to a considerable saving in spectrometer time.
UR - http://www.scopus.com/inward/record.url?scp=0345378100&partnerID=8YFLogxK
U2 - 10.1006/jmra.1993.1248
DO - 10.1006/jmra.1993.1248
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AN - SCOPUS:0345378100
SN - 1064-1858
VL - 105
SP - 59
EP - 64
JO - Journal of Magnetic Resonance
JF - Journal of Magnetic Resonance
IS - 1
ER -