Abstract
Rest tremor is one of the most prominent clinical features of Parkinson's disease (PD). Here, we hypothesized that cortico-basal ganglia neurons tend to fire in a pattern that matches PD tremor frequency, suggesting a resonance phenomenon. We recorded spiking activity in the primary motor cortex (M1) and globus pallidus external segment of 2 female nonhuman primates, before and after parkinsonian state induction with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. The arm of nonhuman primates was passively rotated at seven different frequencies surrounding and overlapping PD tremor frequency. We found entrainment of the spiking activity to arm rotation and a significant sharpening of the tuning curves in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine state, with a peak response at frequencies that matched the frequency of PD tremor. These results reveal increased sensitivity of the cortico-basal ganglia network to tremor frequency and could indicate that this network acts not only as a tremor switch but is involved in setting its frequency.
Original language | English |
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Pages (from-to) | 7712-7722 |
Number of pages | 11 |
Journal | Journal of Neuroscience |
Volume | 43 |
Issue number | 45 |
DOIs | |
State | Published - 8 Nov 2023 |
Bibliographical note
Publisher Copyright:© 2023 the authors.
Funding
This study was partially supported by ISF, DFG (Retune, TRR 275), Israel- 29 China Bin-national science foundation to HB. This study was partially supported by grants from 30 the Israel Science Foundation - ISF, no. 2128/19 (RE). We thank Tuvia Kurz for the primate 31 illustration in Figure 1.
Funders | Funder number |
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Deutsche Forschungsgemeinschaft | TRR 275 |
Israel Science Foundation | 2128/19 |