Triple dissociation in the medial temporal lobe in memory for context .

Y. Hoffman, N. Regev, A. Maril

Research output: Contribution to conferencePaperpeer-review

Abstract

Recent studies of recognition have mapped context processing to the parahippocampus and item recognition to the perirhinal cortex. Context was typically addressed solely from the perspective of item memory. Here we applied a novel measure of memory for context itself, while ensuring that it was still cognitively processed incidentally at both study and test. Of interest were the questions: 1) Will the same activation for context be observed when memory for the context itself is measured and 2) Would a memory trace for the context be affected by target status? 18 subjects were asked at study to incidentally encode black target words (item) which were superimposed on larger gray words (context) in composite stimuli. Participants were scanned during a subsequent recognition test where they were asked to make an old-new judgment on the black word. Test included four types of stimuli which were obtained by crossing the target-context dimension with old-new status. Memory for the context (old vs. new) was assessed twice, once for each of the two target conditions. This design enabled the definition of Hits and False alarms to be applied not only to target items but also to the trial-by-trial changing context. Anterior and posterior PHc activation patterns revealed significant interactions of context (old vs. new) with Response (nyeso vs. nnoo). These activations were completely lateralized by target condition. This triple dissociation suggests that memory for context can be represented in one of two distinct traces, one for context-item information and another for context out of bound.
Original languageAmerican English
StatePublished - 2011
Event18th Annual Meeting of the Cognitive Neuro Society (CNS). - San Francisco, California, United States
Duration: 2 Apr 20115 Apr 2011

Conference

Conference18th Annual Meeting of the Cognitive Neuro Society (CNS).
Country/TerritoryUnited States
CitySan Francisco, California
Period2/04/115/04/11

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