Abstract
Trinucleotide repeats (TNRs) have been primarily connected to neurologic and neuromuscular diseases, with few specific TNRs linked with various tumors. Here we conduct a genome-wide analysis and show that TNRs are five times more prevalent in cancer-related human genes. Interestingly, we also find that cancer-related genes are significantly longer than other genes. Our results suggest that genes containing TNRs are more prone to mutagenesis. The database of TNR genes can be used as a list of candidate cancer-related genes.
| Original language | English |
|---|---|
| Pages (from-to) | 14-18 |
| Number of pages | 5 |
| Journal | Trends in Genetics |
| Volume | 24 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2008 |
| Externally published | Yes |
Bibliographical note
Funding Information:The authors thank E.Y. Levanon for many helpful comments and suggestions and for critical reading of the manuscript. Y.H. is supported by the Foulkes Foundation fellowship for MD-PhD students. G.R. holds the Djerassi Chair in Oncology at the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. The authors also thank the Paamei Tikva fund for their generous support of our research. E.E. is supported by an Alon fellowship at Tel-Aviv University.
Funding
The authors thank E.Y. Levanon for many helpful comments and suggestions and for critical reading of the manuscript. Y.H. is supported by the Foulkes Foundation fellowship for MD-PhD students. G.R. holds the Djerassi Chair in Oncology at the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. The authors also thank the Paamei Tikva fund for their generous support of our research. E.E. is supported by an Alon fellowship at Tel-Aviv University.
| Funders | Funder number |
|---|---|
| Foulkes Foundation | |
| Tel Aviv University |
