Abstract
Abstract: Transcriptional regulation is pivotal for development and differentiation of organisms. Transcription of eukaryotic protein-coding genes by RNA polymerase II (Pol II) initiates at the core promoter. Core promoters, which encompass the transcription start site, may contain functional core promoter elements, such as the TATA box, initiator, TCT and downstream core promoter element. TRF2 (TATA-box-binding protein-related factor 2) does not bind TATA box-containing promoters. Rather, it is recruited to core promoters via sequences other than the TATA box. We review the recent findings implicating TRF2 as a basal transcription factor in the regulation of diverse biological processes and specialized transcriptional programs.
| Original language | English |
|---|---|
| Journal | Transcription |
| Volume | 6 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1 Jan 2015 |
Bibliographical note
Publisher Copyright:© 2015 The Author(s). Published with license by Taylor & Francis Group, LLC.
Funding
TRF2-related research in the Juven-Gershon lab was supported by grants from the Israel Science Foundation (no. 798/ 10) and the European Union Seventh Framework Programme (Marie Curie International Reintegration Grant; no. 256491).
| Funders | Funder number |
|---|---|
| Israel Science Foundation | |
| Seventh Framework Programme | 256491 |
| Israel Science Foundation | 798/ 10 |
Keywords
- DPE
- RNA Pol II transcription
- TBP-related factors
- TCT
- TRF2
- core promoter elements/motifs
- embryonic development
- histone gene cluster
- ribosomal protein genes
- spermiogenesis