TRF2: TRansForming the view of general transcription factors

Yonathan Zehavi, Adi Kedmi, Diana Ideses, Tamar Juven-Gershon

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Abstract: Transcriptional regulation is pivotal for development and differentiation of organisms. Transcription of eukaryotic protein-coding genes by RNA polymerase II (Pol II) initiates at the core promoter. Core promoters, which encompass the transcription start site, may contain functional core promoter elements, such as the TATA box, initiator, TCT and downstream core promoter element. TRF2 (TATA-box-binding protein-related factor 2) does not bind TATA box-containing promoters. Rather, it is recruited to core promoters via sequences other than the TATA box. We review the recent findings implicating TRF2 as a basal transcription factor in the regulation of diverse biological processes and specialized transcriptional programs.

Original languageEnglish
JournalTranscription
Volume6
Issue number1
DOIs
StatePublished - 1 Jan 2015

Bibliographical note

Publisher Copyright:
© 2015 The Author(s). Published with license by Taylor & Francis Group, LLC.

Keywords

  • DPE
  • RNA Pol II transcription
  • TBP-related factors
  • TCT
  • TRF2
  • core promoter elements/motifs
  • embryonic development
  • histone gene cluster
  • ribosomal protein genes
  • spermiogenesis

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