Treatment of Metastatic Adrenal Cortical Carcinoma with Etoposide (VP-16) and Cisplatin after Failure with o,p′DDD: Clinical Case Reports

J. Zidan, M. Shpendler, E. Robinson

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

A 42-year-old woman with liver metastasis from adrenal cortical carcinoma was treated with mitotane (o,p′DDD) for 11 months with a minimal response. Mitotane was stopped because of severe adverse effects. Thereafter a combination of cisplatin and etoposide was given every 3 weeks. A partial response was achieved after five chemotherapy courses. Following this chemotherapy, the patient had a surgical excision of the liver metastasis and entered into a complete remission for 17 months. Etoposide plus cisplatin may be an active combination for the treatment of adrenal cortical carcinoma.

Original languageEnglish
Pages (from-to)229-231
Number of pages3
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume19
Issue number3
DOIs
StatePublished - Jun 1996
Externally publishedYes

Keywords

  • Adrenal cortical carcinoma
  • Cisplatin
  • Etoposide
  • Mitotane
  • Therapy

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