Treatment of Disease by Modulation of SIRT6

H. Cohen (Inventor), Yariv Kanfi (Inventor), Sivan Elhanati (Inventor)

Research output: Patent


An aspect of an embodiment of the invention relates to providing treatment of disease, in particular age-related disease, through increasing or decreasing the activity of SIRT6 protein. This may be accomplished through upregulation and downregulation of expression of SIRT6 in mammals. It has been found by the inventors that mice over-expressing SIRT6 have a longer lifespan in comparison to control mice, indicating that increasing SIRT6 expression can lengthen lifespan of mammals. Agents which modulate SIRT6 expression through, for example binding to 3′UTR region of human mRNA encoding SIRT6 or by blocking binding of agents to 3′UTR region of human mRNA encoding SIRT6, have been identified.
Original languageAmerican English
Patent number9,422,561
StatePublished - 2016


Dive into the research topics of 'Treatment of Disease by Modulation of SIRT6'. Together they form a unique fingerprint.

Cite this