Abstract
Follicular lymphoma (FL) is the most common subtype of indolent non-Hodgkin lymphoma. Patients with stage I disease are usually treated with radiotherapy (RT). In previous studies, mostly from the pre positron emission tomography–computed tomography (PET-CT) era, the 5 year progression-free survival (PFS) and overall survival (OS) rates of stage I disease were 60–80% and 80–93%, respectively. This study retrospectively evaluated the outcome of stage I FL which was treated with involved field RT in the PET-CT era between 2002 and 2015. Ninety-one patients were enrolled. Five year PFS and OS rates were 73% and 97%, respectively. Relapse occurred in 19 (21%) patients, 74% occurring outside the radiation field. In conclusion, PET-CT staging of clinical stage I FL may contribute to the improved prognosis in patients treated with RT compared to historical cohorts, possibly due to better identification of “genuine” stage I disease.
| Original language | English |
|---|---|
| Pages (from-to) | 1163-1171 |
| Number of pages | 9 |
| Journal | Leukemia and Lymphoma |
| Volume | 59 |
| Issue number | 5 |
| DOIs | |
| State | Published - 4 May 2018 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2017 Informa UK Limited, trading as Taylor & Francis Group.
Keywords
- Follicular lymphoma
- immunotherapy
- positron emission tomography
- radiotherapy
- rituximab
