Abstract
Xenografting of normal and transformed mammalian tissues and cells to chick embryos has been performed for almost 100 years. Embryonic stem cells, derived more than 25 years ago from murine, and more than 10 years ago from human blastocysts, have transformed many fields of biological research. There is a growing body of studies combining these two widely-used experimental systems. This review surveys those reports in which murine or human embryonic stem cells, or differentiated derivatives of these pluripotent stem cells, were transplanted to embryonated chick eggs. Many of these studies have utilized the unique characteristics of both experimental models to obtain answers to developmental questions that are difficult or impossible to approach with xenografting to adult rodents or tissue culture-only techniques.
| Original language | English |
|---|---|
| Pages (from-to) | 473-483 |
| Number of pages | 11 |
| Journal | Stem Cell Reviews and Reports |
| Volume | 6 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 2010 |
Bibliographical note
Funding Information:Acknowledgements I would like to express my thanks to the Adelson Medical Research Foundation, Israel Academy of Sciences, Familial Dysautonomia Foundation, and the Israel Ministry of Health for supporting my hESC research over the past 8 years.
Funding
Acknowledgements I would like to express my thanks to the Adelson Medical Research Foundation, Israel Academy of Sciences, Familial Dysautonomia Foundation, and the Israel Ministry of Health for supporting my hESC research over the past 8 years.
| Funders | Funder number |
|---|---|
| Adelson Medical Research Foundation | |
| Dysautonomia Foundation | |
| Academy of Leisure Sciences | |
| Ministry of Health, State of Israel |
Keywords
- Chick embryo
- Differentiation
- Human embryonic stem cells
- Migration
- Neural crest
- Xenograft
