Transplantation of Mammalian Embryonic Stem Cells and Their Derivatives to Avian Embryos

Ronald S. Goldstein

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Xenografting of normal and transformed mammalian tissues and cells to chick embryos has been performed for almost 100 years. Embryonic stem cells, derived more than 25 years ago from murine, and more than 10 years ago from human blastocysts, have transformed many fields of biological research. There is a growing body of studies combining these two widely-used experimental systems. This review surveys those reports in which murine or human embryonic stem cells, or differentiated derivatives of these pluripotent stem cells, were transplanted to embryonated chick eggs. Many of these studies have utilized the unique characteristics of both experimental models to obtain answers to developmental questions that are difficult or impossible to approach with xenografting to adult rodents or tissue culture-only techniques.

Original languageEnglish
Pages (from-to)473-483
Number of pages11
JournalStem Cell Reviews and Reports
Issue number3
StatePublished - 2010

Bibliographical note

Funding Information:
Acknowledgements I would like to express my thanks to the Adelson Medical Research Foundation, Israel Academy of Sciences, Familial Dysautonomia Foundation, and the Israel Ministry of Health for supporting my hESC research over the past 8 years.


  • Chick embryo
  • Differentiation
  • Human embryonic stem cells
  • Migration
  • Neural crest
  • Xenograft


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