Transient neutropenia induced by intravenous immune globulin

To the Editor: Intravenous immune globulin is used as an immunomodulatory agent in various autoimmune diseases.¹ Adverse effects are uncommon but may include vasomotor symptoms such as chills, nausea, flushing, tightness of the chest, and wheezing.² Hemolysis, thrombosis, alopecia, and liver-function disturbances have also been reported.^{3 4 5} Recently, we encountered a 36-year-old woman with active systemic lupus erythematosus in whom treatment with prednisone (60 mg daily) and azathioprine (200 mg daily) had failed to control the manifestations of the disease. Therefore, we decided to attempt a trial of immune globulin (Sandoglobulin, Sandoz), given in two courses (400 mg per kilogram of. . .