Trajectories of Autism Symptom Severity Change During Early Childhood

Einat Waizbard-Bartov; Emilio Ferrer; Gregory S. Young; Brianna Heath; Sally Rogers; Christine Wu Nordahl; Marjorie Solomon; David G. Amaral

doi:10.1007/s10803-020-04526-z

Trajectories of Autism Symptom Severity Change During Early Childhood

Einat Waizbard-Bartov, Emilio Ferrer, Gregory S. Young, Brianna Heath, Sally Rogers, Christine Wu Nordahl, Marjorie Solomon, David G. Amaral

University of California at Davis

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Autism symptom severity change was evaluated during early childhood in 125 children diagnosed with autism spectrum disorder (ASD). Children were assessed at approximately 3 and 6 years of age for autism symptom severity, IQ and adaptive functioning. Each child was assigned a change score, representing the difference between ADOS Calibrated Severity Scores (CSS) at the two ages. A Decreased Severity Group (28.8%) decreased by 2 or more points; a Stable Severity Group (54.4%) changed by 1 point or less; and an Increased Severity Group (16.8%) increased by 2 or more points. Girls tended to decrease in severity more than boys and increase in severity less than boys. There was no clear relationship between intervention history and membership in the groups.

Original language	English
Pages (from-to)	227-242
Number of pages	16
Journal	Journal of Autism and Developmental Disorders
Volume	51
Issue number	1
DOIs	https://doi.org/10.1007/s10803-020-04526-z
State	Published - Jan 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020, The Author(s).

Funding

This research was supported by NIH Grant R01MH103371 to Dr. Amaral and NIH R01MH104438 to Dr. Nordahl. This project was also supported by the MIND Institute Intellectual and Developmental Disabilities Research Center (U54HD079125). Dr. Solomon was supported by NIH Grants R01MH106518 and R01MH103284 and T32 MH073124, and by the Simons Foundation. This research was supported by an Autism Center of Excellence grant awarded by the National Institute of Child Health and Development (NICHD) (P50 HD093079). The authors would like to thank the families and children who participated in the Autism Phenome Project and Girls with Autism Imaging of Neurodevelopment studies. This research was funded by grants from the NIH (R01MH103371 and R01MH104438) to Dr. Amaral. This project was also funded by the MIND Institute Intellectual and Developmental Disabilities Research Center (U54HD079125). Dr. Solomon was supported by NIH Grants R01MH106518 and R01MH103284 and T32 MH073124, and by the Simons Foundation, Dr. Nordahl was supported by NIH Grant R01MH104438. This research was supported by an Autism Center of Excellence grant awarded by the National Institute of Child Health and Development (NICHD) (P50 HD093079). Acknowledgments

Funders	Funder number
MIND Institute Intellectual and Developmental Disabilities Research Center	U54HD079125, R01MH106518, R01MH103284, T32 MH073124
National Institutes of Health	R01MH103371, R01MH104438
National Institute of Child Health and Human Development	P50 HD093079
Simons Foundation

Keywords

Autism spectrum disorder
Early childhood
Sex differences
Symptom severity

Access to Document

10.1007/s10803-020-04526-z

Cite this

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abstract = "Autism symptom severity change was evaluated during early childhood in 125 children diagnosed with autism spectrum disorder (ASD). Children were assessed at approximately 3 and 6 years of age for autism symptom severity, IQ and adaptive functioning. Each child was assigned a change score, representing the difference between ADOS Calibrated Severity Scores (CSS) at the two ages. A Decreased Severity Group (28.8%) decreased by 2 or more points; a Stable Severity Group (54.4%) changed by 1 point or less; and an Increased Severity Group (16.8%) increased by 2 or more points. Girls tended to decrease in severity more than boys and increase in severity less than boys. There was no clear relationship between intervention history and membership in the groups.",

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Trajectories of Autism Symptom Severity Change During Early Childhood

Abstract

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