Towards In Vivo Tumor Detection Using Polarization and Wavelength Characteristics of Self-Assembled Gold Nanorods

Ke Hou, Dror Fixler, Bing Han, Lin Shi, Idit Feder, Hamootal Duadi, Xiaoli Wang, Zhiyong Tang

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

This work suggests a novel concept for sensing the back-reflected and absorbed light at two polarization states and at several wavelengths based on self-assembled gold nanorods (SGNs). While the SGNs are flowing in the bloodstream, the reflected light has a low degree of polarization at the specific wavelength. In comparison, when the SGNs are not moving, such as when the SGNs are located in a tumor, the reflected light has a high degree of polarization. Impressively, the SGNs structures further display a considerably improved contrast in the diffusion reflection (DR) system. Such characteristics provide a new strategy for possible in vivo detection of a tumor with enhanced resolution.

Original languageEnglish
Pages (from-to)736-739
Number of pages4
JournalChemNanoMat
Volume3
Issue number10
DOIs
StatePublished - Oct 2017

Bibliographical note

Publisher Copyright:
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Funding

The authors acknowledge financial support from National Key Basic Research Program of China (2014CB931801 and 2016YF A0200700, Z.Y.T.), National Natural Science Foundation of China (21475029 and 91427302, Z.Y.T.), Frontier Science Key Project of the Chinese Academy of Sciences (QYZDJ-SSW-SLH038, Z.Y.T.), Instrument Developing Project of the Chinese Academy of Sciences (YZ201311, Z.Y.T.), CAS-CSIRO Cooperative Research Program (GJHZ1503, Z.Y.T.), “Strategic Priority Research Program” of Chinese Academy of Sciences (XD A09040100, Z.Y.T.), and the President’s International Fellowship Initiative, Chinese Academy of Sciences (PIFI2017VMB0019).

FundersFunder number
CAS-CSIROGJHZ1503, PIFI2017VMB0019, XD A09040100
National Natural Science Foundation of China21475029, 91427302
Chinese Academy of SciencesYZ201311
Chinese Academy of Sciences Key ProjectQYZDJ-SSW-SLH038
National Basic Research Program of China (973 Program)2016YF A0200700, 2014CB931801

    Keywords

    • bioimaging
    • gold
    • nanorods
    • polarization
    • self-assembly

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