Towards a consensus on alzheimer’s disease comorbidity?

Iska Avitan, Yudit Halperin, Trishna Saha, Naamah Bloch, Dana Atrahimovich, Baruh Polis, Abraham O. Samson, Ori Braitbard

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Alzheimer’s disease (AD) is often comorbid with other pathologies. First, we review shortly the diseases most associated with AD in the clinic. Then we query PubMed citations for the co-occurrence of AD with other diseases, using a list of 400 common pathologies. Significantly, AD is found to be associated with schizophrenia and psychosis, sleep insomnia and apnea, type 2 diabetes, atherosclerosis, hypertension, cardiovascular diseases, obesity, fibrillation, osteoporosis, arthritis, glaucoma, metabolic syndrome, pain, herpes, HIV, alcoholism, heart failure, migraine, pneumonia, dyslipidemia, COPD and asthma, hearing loss, and tobacco smoking. Trivially, AD is also found to be associated with several neurodegenerative diseases, which are disregarded. Notably, our predicted results are consistent with the previously published clinical data and correlate nicely with individual publications. Our results emphasize risk factors and promulgate diseases often associated with AD. Interestingly, the comorbid diseases are often degenerative diseases exacerbated by reactive oxygen species, thus underlining the potential role of antioxidants in the treatment of AD and comorbid diseases.

Original languageEnglish
Article number4360
JournalJournal of Clinical Medicine
Issue number19
StatePublished - 1 Oct 2021

Bibliographical note

Funding Information:
Funding: This research was funded by the Ginsburg Foundation and Katz family foundation to AOS.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.


  • Alzheimer’s disease
  • Bioinformatics
  • Comorbidity
  • Oxidative stress


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