TOR Complex 2- independent mutations in the regulatory PIF pocket of Gad8^AKT1/SGK1 define separate branches of the stress response mechanisms in fission yeast

Keyphrases

• Stress Response Pathway 100%
• Fission Yeast 100%
• Target of Rapamycin 100%
• SGK1 100%
• PIF Pocket 100%
• Gad8 100%
• MTOR Complex 2 (mTORC2) 90%
• AGC Kinase 40%
• Phosphorylation 30%
• Developmental Processes 20%
• Stress Conditions 20%
• Kinase Activity 20%
• Orthologues 20%
• Phosphorylation Sites 20%
• PDK1 20%
• Growth Process 10%
• Stress Response 10%
• Molecular Dynamics Simulation 10%
• Activity-dependent 10%
• Protein Kinase 10%
• Starvation 10%
• Proliferation Process 10%
• Conserved Motif 10%
• Mutant Alleles 10%
• Substrate Binding 10%
• Separable Functions 10%
• Osmotic Stress 10%
• Nutrient Stress 10%
• Survival Process 10%
• Two-step Mechanism 10%
• TORC1 10%
• Fission Yeast Schizosaccharomyces Pombe 10%
• Genotoxic Stress Response 10%
• Multi-subunit Protein Complexes 10%
• High Flexibility 10%

Biochemistry, Genetics and Molecular Biology

• Fission Yeast 100%
• Mammalian Target of Rapamycin Complex 2 100%
• Phosphotransferase 27%
• Kinase 27%
• Phosphoinositide-Dependent Kinase-1 18%
• Dynamics 9%
• Protein Complexes 9%
• Allele 9%
• Mammalian Target of Rapamycin Complex 1 9%
• Schizosaccharomyces Pombe 9%
• Protein Kinases 9%

Pharmacology, Toxicology and Pharmaceutical Science

• Mammalian Target of Rapamycin Complex 2 100%
• Fission Yeast 100%
• Phosphotransferase 27%
• Phosphoinositide Dependent Protein Kinase 1 18%
• Mammalian Target of Rapamycin Complex 1 9%
• Schizosaccharomyces Pombe 9%
• Target of Rapamycin Kinase 9%
• Rapamycin 9%