Tissue-like phantoms as a platform for inserted fluorescence nano-probes

Tsviya Nayhoz; Eran A. Barnoy; Dror Fixler

doi:10.3390/ma9110926

Tissue-like phantoms as a platform for inserted fluorescence nano-probes

Tsviya Nayhoz, Eran A. Barnoy, Dror Fixler

Bar-Ilan University - The Alexander Kofkin Faculty of Engineering

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Tissue-like phantoms are widely used as a model for mimicking the optical properties of live tissue. This paper presents the results of a diffusion reflection method and fluorescence lifetime imaging microscopy measurements of fluorescein-conjugated gold nanorods in solution, as well as inserted in solid tissue-imitating phantoms. A lack of consistency between the fluorescence lifetime results of the solutions and the phantoms raises a question about the ability of tissue-like phantoms to maintain the optical properties of inserted contrast agents.

Original language	English
Article number	926
Journal	Materials
Volume	9
Issue number	11
DOIs	https://doi.org/10.3390/ma9110926
State	Published - 15 Nov 2016

Bibliographical note

Publisher Copyright:
© 2016 by the authors.

Keywords

Diffusion reflection
Dual-modal imaging
FLT imaging (FLIM)
Fluorescence lifetime (FLT)
Tissue-like phantoms

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10.3390/ma9110926

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abstract = "Tissue-like phantoms are widely used as a model for mimicking the optical properties of live tissue. This paper presents the results of a diffusion reflection method and fluorescence lifetime imaging microscopy measurements of fluorescein-conjugated gold nanorods in solution, as well as inserted in solid tissue-imitating phantoms. A lack of consistency between the fluorescence lifetime results of the solutions and the phantoms raises a question about the ability of tissue-like phantoms to maintain the optical properties of inserted contrast agents.",

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AB - Tissue-like phantoms are widely used as a model for mimicking the optical properties of live tissue. This paper presents the results of a diffusion reflection method and fluorescence lifetime imaging microscopy measurements of fluorescein-conjugated gold nanorods in solution, as well as inserted in solid tissue-imitating phantoms. A lack of consistency between the fluorescence lifetime results of the solutions and the phantoms raises a question about the ability of tissue-like phantoms to maintain the optical properties of inserted contrast agents.

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Tissue-like phantoms as a platform for inserted fluorescence nano-probes

Abstract

Bibliographical note

Keywords

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