Thyroid hormones and cardiac arrhythmias

Narcis Tribulova; Vladimir Knezl; Asher Shainberg; Shingo Seki; Tomas Soukup

doi:10.1016/j.vph.2009.10.001

Thyroid hormones and cardiac arrhythmias

Narcis Tribulova, Vladimir Knezl, Asher Shainberg, Shingo Seki, Tomas Soukup

The Mina and Everard Goodman Faculty of Life Sciences - at Bar-Ilan University

Research output: Contribution to journal › Review article › peer-review

66 Scopus citations

Abstract

Thyroid hormone plays an important role in cardiac electrophysiology and Ca²⁺ handling through both genomic and nongenomic mechanisms of action, while both actions can interfere. Chronic changes in the amount of circulating thyroid hormone due to thyroid dysfunction or systemic disease result in structural, electrophysiological and Ca²⁺ handling remodeling, while acute changes may affect basal activity of cardiac cells membrane systems. Consequently, long-term or rapid modulation of sarcolemmal ion channels, Ca²⁺ cycling proteins and intercellular communicating channels by thyroid hormone may affect heart function as well as susceptibility of the heart to arrhythmias. This aspect including pro- and anti-arrhythmic potential of thyroid hormone is highlighted in this review.

Original language	English
Pages (from-to)	102-112
Number of pages	11
Journal	Vascular Pharmacology
Volume	52
Issue number	3-4
DOIs	https://doi.org/10.1016/j.vph.2009.10.001
State	Published - Mar 2010

Bibliographical note

Funding Information:
This work was partially supported by Slovak VEGA 2/0049/09 and APVV 51-059505 , 51-017905 grants as well as by Czech GACR 304/08/0256 and AVOZ 50110509 grants.

Funding

This work was partially supported by Slovak VEGA 2/0049/09 and APVV 51-059505 , 51-017905 grants as well as by Czech GACR 304/08/0256 and AVOZ 50110509 grants.

Funders	Funder number
Vedecká Grantová Agentúra MŠVVaŠ SR a SAV	2/0049/09, GACR 304/08/0256, 51-017905, APVV 51-059505, AVOZ 50110509

Keywords

Arrhythmias
Ca handling
Connexin-43
Ion channels
Thyroid hormone

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10.1016/j.vph.2009.10.001

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title = "Thyroid hormones and cardiac arrhythmias",

abstract = "Thyroid hormone plays an important role in cardiac electrophysiology and Ca2+ handling through both genomic and nongenomic mechanisms of action, while both actions can interfere. Chronic changes in the amount of circulating thyroid hormone due to thyroid dysfunction or systemic disease result in structural, electrophysiological and Ca2+ handling remodeling, while acute changes may affect basal activity of cardiac cells membrane systems. Consequently, long-term or rapid modulation of sarcolemmal ion channels, Ca2+ cycling proteins and intercellular communicating channels by thyroid hormone may affect heart function as well as susceptibility of the heart to arrhythmias. This aspect including pro- and anti-arrhythmic potential of thyroid hormone is highlighted in this review.",

keywords = "Arrhythmias, Ca handling, Connexin-43, Ion channels, Thyroid hormone",

author = "Narcis Tribulova and Vladimir Knezl and Asher Shainberg and Shingo Seki and Tomas Soukup",

note = "Funding Information: This work was partially supported by Slovak VEGA 2/0049/09 and APVV 51-059505 , 51-017905 grants as well as by Czech GACR 304/08/0256 and AVOZ 50110509 grants.",

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AU - Knezl, Vladimir

AU - Shainberg, Asher

AU - Seki, Shingo

AU - Soukup, Tomas

N1 - Funding Information: This work was partially supported by Slovak VEGA 2/0049/09 and APVV 51-059505 , 51-017905 grants as well as by Czech GACR 304/08/0256 and AVOZ 50110509 grants.

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AB - Thyroid hormone plays an important role in cardiac electrophysiology and Ca2+ handling through both genomic and nongenomic mechanisms of action, while both actions can interfere. Chronic changes in the amount of circulating thyroid hormone due to thyroid dysfunction or systemic disease result in structural, electrophysiological and Ca2+ handling remodeling, while acute changes may affect basal activity of cardiac cells membrane systems. Consequently, long-term or rapid modulation of sarcolemmal ion channels, Ca2+ cycling proteins and intercellular communicating channels by thyroid hormone may affect heart function as well as susceptibility of the heart to arrhythmias. This aspect including pro- and anti-arrhythmic potential of thyroid hormone is highlighted in this review.

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Thyroid hormones and cardiac arrhythmias

Abstract

Bibliographical note

Funding

Keywords

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