Thyroid hormone plays an important role in cardiac electrophysiology and Ca2+ handling through both genomic and nongenomic mechanisms of action, while both actions can interfere. Chronic changes in the amount of circulating thyroid hormone due to thyroid dysfunction or systemic disease result in structural, electrophysiological and Ca2+ handling remodeling, while acute changes may affect basal activity of cardiac cells membrane systems. Consequently, long-term or rapid modulation of sarcolemmal ion channels, Ca2+ cycling proteins and intercellular communicating channels by thyroid hormone may affect heart function as well as susceptibility of the heart to arrhythmias. This aspect including pro- and anti-arrhythmic potential of thyroid hormone is highlighted in this review.
Bibliographical noteFunding Information:
This work was partially supported by Slovak VEGA 2/0049/09 and APVV 51-059505 , 51-017905 grants as well as by Czech GACR 304/08/0256 and AVOZ 50110509 grants.
- Ca handling
- Ion channels
- Thyroid hormone