TY - JOUR
T1 - Thrombophilia is common in women with idiopathic pregnancy loss and is associated with late pregnancy wastage
AU - Sarig, Galit
AU - Younis, Johnny S.
AU - Hoffman, Ron
AU - Lanir, Naomi
AU - Blumenfeld, Zeev
AU - Brenner, Benjamin
N1 - Funding Information:
Supported by Israel’s Ministry of Health.
PY - 2002
Y1 - 2002
N2 - Objective: To describe the characteristics of thrombophilia in women with idiopathic pregnancy loss. Design: Prospective observational study. Setting: Tertiary referral center in a teaching academic hospital. Patient(s): One hundred forty-five patients with repeated pregnancy loss and 145 matched controls. Intervention(s): Prospective assessment of thrombophilia in patients and controls. Main Outcome Measure(s): Prevalence of activated protein C (APC) resistance, protein C, protein S, and antithrombin III deficiencies, antiphospholipid antibodies, factor V Leiden, factor II G20210A, and MTHFR C677T mutations. Result(s): At least one thrombophilic defect was found in 66% of study group patients compared with 28% in control group patients. Combined thrombophilic defects were documented in 21% of women with pregnancy loss compared with 5.5% of control patients. Late pregnancy wastage occurred more frequently in women with thrombophilia compared with women without thrombophilia (160/429 [37%] vs. 39/162 [24%], respectively). APC resistance was documented in 39% of women with pregnancy loss compared with 3% of the control patients. APC resistance without factor V Leiden mutation was documented in 18% of women with pregnancy loss compared with none of the controls. While factor V Leiden mutation was more common in women with pregnancy loss (25% vs. 7.6%), factor II G20210A and homozygosity for MTHFR C677T contributed to pregnancy loss only in the presence of other thrombophilia. Conclusion(s): Thrombophilia was found in the majority (66%) of women with idiopathic pregnancy loss. APC resistance with or without factor V Leiden mutation is the most common thrombophilic defect, and combined thrombophilia is a frequent finding in women with pregnancy loss. Thrombophilia is associated with increased frequency of late pregnancy wastage.
AB - Objective: To describe the characteristics of thrombophilia in women with idiopathic pregnancy loss. Design: Prospective observational study. Setting: Tertiary referral center in a teaching academic hospital. Patient(s): One hundred forty-five patients with repeated pregnancy loss and 145 matched controls. Intervention(s): Prospective assessment of thrombophilia in patients and controls. Main Outcome Measure(s): Prevalence of activated protein C (APC) resistance, protein C, protein S, and antithrombin III deficiencies, antiphospholipid antibodies, factor V Leiden, factor II G20210A, and MTHFR C677T mutations. Result(s): At least one thrombophilic defect was found in 66% of study group patients compared with 28% in control group patients. Combined thrombophilic defects were documented in 21% of women with pregnancy loss compared with 5.5% of control patients. Late pregnancy wastage occurred more frequently in women with thrombophilia compared with women without thrombophilia (160/429 [37%] vs. 39/162 [24%], respectively). APC resistance was documented in 39% of women with pregnancy loss compared with 3% of the control patients. APC resistance without factor V Leiden mutation was documented in 18% of women with pregnancy loss compared with none of the controls. While factor V Leiden mutation was more common in women with pregnancy loss (25% vs. 7.6%), factor II G20210A and homozygosity for MTHFR C677T contributed to pregnancy loss only in the presence of other thrombophilia. Conclusion(s): Thrombophilia was found in the majority (66%) of women with idiopathic pregnancy loss. APC resistance with or without factor V Leiden mutation is the most common thrombophilic defect, and combined thrombophilia is a frequent finding in women with pregnancy loss. Thrombophilia is associated with increased frequency of late pregnancy wastage.
KW - Activated protein C resistance
KW - Factor V Leiden
KW - Pregnancy loss
KW - Thrombophilia
UR - http://www.scopus.com/inward/record.url?scp=0036149892&partnerID=8YFLogxK
U2 - 10.1016/S0015-0282(01)02971-5
DO - 10.1016/S0015-0282(01)02971-5
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C2 - 11821094
AN - SCOPUS:0036149892
SN - 0015-0282
VL - 77
SP - 342
EP - 347
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 2
ER -