Thiourea dioxide promoted efficient organocatalytic one-pot synthesis of a library of novel heterocyclic compounds

Sanny Verma, Subodh Kumar, Suman L. Jain, Bir Sain

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

The utility of thiourea dioxide as an efficient organocatalyst for the library synthesis of novel heterocyclic compounds via one-pot multicomponent coupling reactions is disclosed. Thiourea dioxide is an inexpensive and readily accessible catalyst, resulting in better product yields as compared to the corresponding thiourea as catalyst. Thiourea dioxide is found to be insoluble in various organic solvents and therefore at the end of the reaction products can be separated by extraction with diethyl ether and the recovered catalyst can be used several times with consistent catalytic activity.

Original languageEnglish
Pages (from-to)6943-6948
Number of pages6
JournalOrganic and Biomolecular Chemistry
Volume9
Issue number20
DOIs
StatePublished - 21 Oct 2011
Externally publishedYes

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