Thicker macula in asymptomatic APOE Ɛ4 middle-aged adults at high AD risk

Ygal Rotenstreich, Inbal Sharvit-Ginon, Ifat Sher, Ofira Zloto, Ido Didi Fabian, Amir Abd-Elkader, Aron Weller, Anthony Heymann, Michal Schnaider Beeri, Ramit Ravona-Springer

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Introduction: We compared retinal layers’ thickness between apolipoprotein E (APOE) Ɛ4 carriers and non-carriers in a cohort of cognitively normal middle-aged adults enriched for Alzheimer's disease (AD) risk. Methods: Participants (N = 245) underwent spectral domain optical coherence tomography. Multivariate analyses of covariance adjusting for age, sex, education, and best corrected vision acuity was used to compare retinal thickness between APOE groups. Results: Participants’ mean age was 59.60 (standard deviation = 6.42) with 66.4% women and 32.2% APOE Ɛ4 carriers. Greater macular full thickness was observed in APOE Ɛ4 carriers compared to non-carriers (P =.017), reaching statistical significance for the inner and outer nasal (P =.009 and P =.005, respectively), inner superior (P =.041), and inner and outer inferior (P =.013 and P =.033, respectively) sectors. The differences between APOE groups were mainly driven by the ganglion cell layer (P <.05) and the inner plexiform layer (P <.05). Discussion: A thicker macula is observed already in midlife asymptomatic APOE Ɛ4 carriers at high AD risk.

Original languageEnglish
Article numbere12275
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Issue number1
StatePublished - 2022

Bibliographical note

Publisher Copyright:
© 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.


  • Alzheimer's disease
  • apolipoprotein E Ɛ4 genotype
  • high risk for Alzheimer's disease
  • offspring of Alzheimer's disease patients
  • optical coherence tomography
  • retinal biomarkers
  • retinal layers
  • retinal sectors


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