Thicker macula in asymptomatic APOE Ɛ4 middle-aged adults at high AD risk

Ygal Rotenstreich; Inbal Sharvit-Ginon; Ifat Sher; Ofira Zloto; Ido Didi Fabian; Amir Abd-Elkader; Aron Weller; Anthony Heymann; Michal Schnaider Beeri; Ramit Ravona-Springer

doi:10.1002/dad2.12275

Thicker macula in asymptomatic APOE Ɛ4 middle-aged adults at high AD risk

Ygal Rotenstreich, Inbal Sharvit-Ginon, Ifat Sher, Ofira Zloto, Ido Didi Fabian, Amir Abd-Elkader, Aron Weller, Anthony Heymann, Michal Schnaider Beeri, Ramit Ravona-Springer

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Introduction: We compared retinal layers’ thickness between apolipoprotein E (APOE) Ɛ4 carriers and non-carriers in a cohort of cognitively normal middle-aged adults enriched for Alzheimer's disease (AD) risk. Methods: Participants (N = 245) underwent spectral domain optical coherence tomography. Multivariate analyses of covariance adjusting for age, sex, education, and best corrected vision acuity was used to compare retinal thickness between APOE groups. Results: Participants’ mean age was 59.60 (standard deviation = 6.42) with 66.4% women and 32.2% APOE Ɛ4 carriers. Greater macular full thickness was observed in APOE Ɛ4 carriers compared to non-carriers (P =.017), reaching statistical significance for the inner and outer nasal (P =.009 and P =.005, respectively), inner superior (P =.041), and inner and outer inferior (P =.013 and P =.033, respectively) sectors. The differences between APOE groups were mainly driven by the ganglion cell layer (P <.05) and the inner plexiform layer (P <.05). Discussion: A thicker macula is observed already in midlife asymptomatic APOE Ɛ4 carriers at high AD risk.

Original language	English
Article number	e12275
Journal	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume	14
Issue number	1
DOIs	https://doi.org/10.1002/dad2.12275
State	Published - 2022

Bibliographical note

Publisher Copyright:
© 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.

Funding

This work was supported by the Israel Science Foundation research grant (ISF#1845/16), The National Network of Excellence (NNE) research grant (Teva Pharmaceuticals, NNE#PO AG10077820), the Bader Philanthropies, The LeRoy Schecter Foundation, and Dr. Marina Nissim. The funding organizations had no role in the design or conduct of this research.

Funders	Funder number
NNE
National Network of Excellence
Teva Pharmaceutical Industries	AG10077820
Bader Philanthropies
LeRoy Schecter Foundation
Israel Science Foundation	ISF#1845/16

Keywords

Alzheimer's disease
apolipoprotein E Ɛ4 genotype
high risk for Alzheimer's disease
offspring of Alzheimer's disease patients
optical coherence tomography
retinal biomarkers
retinal layers
retinal sectors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/dad2.12275

Cite this

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title = "Thicker macula in asymptomatic APOE Ɛ4 middle-aged adults at high AD risk",

abstract = "Introduction: We compared retinal layers{\textquoteright} thickness between apolipoprotein E (APOE) Ɛ4 carriers and non-carriers in a cohort of cognitively normal middle-aged adults enriched for Alzheimer's disease (AD) risk. Methods: Participants (N = 245) underwent spectral domain optical coherence tomography. Multivariate analyses of covariance adjusting for age, sex, education, and best corrected vision acuity was used to compare retinal thickness between APOE groups. Results: Participants{\textquoteright} mean age was 59.60 (standard deviation = 6.42) with 66.4% women and 32.2% APOE Ɛ4 carriers. Greater macular full thickness was observed in APOE Ɛ4 carriers compared to non-carriers (P =.017), reaching statistical significance for the inner and outer nasal (P =.009 and P =.005, respectively), inner superior (P =.041), and inner and outer inferior (P =.013 and P =.033, respectively) sectors. The differences between APOE groups were mainly driven by the ganglion cell layer (P <.05) and the inner plexiform layer (P <.05). Discussion: A thicker macula is observed already in midlife asymptomatic APOE Ɛ4 carriers at high AD risk.",

keywords = "Alzheimer's disease, apolipoprotein E Ɛ4 genotype, high risk for Alzheimer's disease, offspring of Alzheimer's disease patients, optical coherence tomography, retinal biomarkers, retinal layers, retinal sectors",

author = "Ygal Rotenstreich and Inbal Sharvit-Ginon and Ifat Sher and Ofira Zloto and Fabian, {Ido Didi} and Amir Abd-Elkader and Aron Weller and Anthony Heymann and Beeri, {Michal Schnaider} and Ramit Ravona-Springer",

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AU - Sher, Ifat

AU - Zloto, Ofira

AU - Fabian, Ido Didi

AU - Abd-Elkader, Amir

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Thicker macula in asymptomatic APOE Ɛ4 middle-aged adults at high AD risk

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

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