Thermoregulatory and locomotor effects of DSIP: Paradoxical interaction with d-amphetamine

Shlomo Yehuda, Abba J. Kastin, David H. Coy

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

A low dose (0.1 mg/kg) of peripherally administered delta sleep-inducing peptide (DSIP) caused hypothermia in rats maintained at 4°C but larger doses (1.0 or 3.0 mg/kg) did not. At 22°C all 3 doses of DSIP caused hyperthermia. The interaction of d-amphetamine with DSIP was dependent on ambient temperature; at 4°C DSIP had no effect on d-amphetamine-induced hypothermia, but at 22°C DSIP reversed the usual d-amphetamine-induced effect of hyperthermia to hypothermia. At 4°C, DSIP also potentiated the hypermotility effects of d-amphetamine but blocked it at 22°C. Many rats receiving DSIP (0.1 mg/kg) and d-amphetamine (15.0 mg/kg) at 22°C paradoxically exhibited what appeared to be sleep. This sleep-like effect was not found after several other doses of DSIP and d-amphetamine, chlorpromazine, or at a cold ambient temperature. Sodium methohexital caused apparent sleep in animals treated with DSIP alone or with DSIP and d-amphetamine, but was unable to induce this effect in rats receiving d-amphetamine alone. The results suggest that the effects of peripherally injected DSIP on body temperature are independent from its effects on locomotion and that both effects are dependent upon ambient temperature.

Original languageEnglish
Pages (from-to)895-900
Number of pages6
JournalPharmacology Biochemistry and Behavior
Volume13
Issue number6
DOIs
StatePublished - Dec 1980
Externally publishedYes

Bibliographical note

Funding Information:
Supported in part by the Medical Research Service of the Veterans Administration and NIH (NS 07664).

Keywords

  • Amphetamine
  • DSIP
  • Locomotion
  • Peptide
  • Sleep
  • Temperature

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