Thermal therapy with magnetic nanoparticles for cell destruction

Adi Vegerhof, Menachem Motei, Arkady Rudinzky, Dror Malka, Rachela Popovtzer, Zeev Zalevsky

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


In this article we suggest a new concept for cell destruction based upon manipulating magnetic nanoparticles (MNPs) by applying external, low frequency alternating magnetic field (AMF) that oscillates the particles, together with focused laser illumination. Assessment of temperature profiles in a head and neck squamous cell carcinoma sample showed that cells with MNPs, treated with AMF (3 Hz, 300 mW) and laser irradiation (30 mW), reached 42°C after 4.5 min, as opposed to cells treated with laser but without AMF. Moreover, a theoretical model was developed to assess the overall theoretical temperature rise, which was shown to be 50% lower than the experimental temperature. Furthermore, we found that the combination of laser irradiation and AMF decreased the number of live cells by ~50%. Thus, the concentrated assembly of laser heating with AMF-induced MNP oscillations leads to more rapid and efficient cell death. These results suggest that the manipulated MNP technique can serve as a superior agent for PTT, with improved cell death capabilities.

Original languageEnglish
Article number#273870
Pages (from-to)4581-4594
Number of pages14
JournalBiomedical Optics Express
Issue number11
StatePublished - 1 Nov 2016

Bibliographical note

Publisher Copyright:
© 2016 Optical Society of America.


  • Biology
  • Blood or tissue constituent monitoring
  • Cell analysis
  • Lasers, pulsed
  • Visible lasers


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