TY - JOUR
T1 - Therapeutic application of Carica papaya leaf extract in the management of human diseases
AU - Singh, Surya P.
AU - Kumar, Sanjay
AU - Mathan, Sivapar V.
AU - Tomar, Munendra Singh
AU - Singh, Rishi Kant
AU - Verma, Praveen Kumar
AU - Kumar, Amit
AU - Kumar, Sandeep
AU - Singh, Rana P.
AU - Acharya, Arbind
N1 - Publisher Copyright:
© 2020, Springer Nature Switzerland AG.
PY - 2020/12
Y1 - 2020/12
N2 - Introduction: Papaya (Carica papaya Linn.) belongs to the family Caricaceae and is well known for its therapeutic and nutritional properties all over the world. The different parts of the papaya plant have been used since ancient times for its therapeutic applications. Herein, we aimed to review the anticancer, anti-inflammatory, antidiabetic and antiviral activities of papaya leaf. Methods: All information presented in this review article regarding the therapeutic application of Carica papaya leaf extract has been acquired by approaching various electronic databases, including Scopus, Google scholar, Web of science, and PubMed. The keywords Carica papaya, anticancer, anti-inflammatory, immunomodulatory, and phytochemicals were explored until December 2019. Results: The papaya plant, including fruit, leaf, seed, bark, latex, and their ingredients play a major role in the management of disease progression. Carica papaya leaf contains active components such as alkaloids, glycosides, tannins, saponins, and flavonoids, which are responsible for its medicinal activity. Additionally, the leaf juice of papaya increases the platelet counts in people suffering from dengue fever. Conclusion: The major findings revealed that papaya leaf extract has strong medicinal properties such as antibacterial, antiviral, antitumor, hypoglycaemic and anti-inflammatory activity. Furthermore, clinical trials are needed to explore the medicative potential of papaya leaf. [Figure not available: see fulltext.].
AB - Introduction: Papaya (Carica papaya Linn.) belongs to the family Caricaceae and is well known for its therapeutic and nutritional properties all over the world. The different parts of the papaya plant have been used since ancient times for its therapeutic applications. Herein, we aimed to review the anticancer, anti-inflammatory, antidiabetic and antiviral activities of papaya leaf. Methods: All information presented in this review article regarding the therapeutic application of Carica papaya leaf extract has been acquired by approaching various electronic databases, including Scopus, Google scholar, Web of science, and PubMed. The keywords Carica papaya, anticancer, anti-inflammatory, immunomodulatory, and phytochemicals were explored until December 2019. Results: The papaya plant, including fruit, leaf, seed, bark, latex, and their ingredients play a major role in the management of disease progression. Carica papaya leaf contains active components such as alkaloids, glycosides, tannins, saponins, and flavonoids, which are responsible for its medicinal activity. Additionally, the leaf juice of papaya increases the platelet counts in people suffering from dengue fever. Conclusion: The major findings revealed that papaya leaf extract has strong medicinal properties such as antibacterial, antiviral, antitumor, hypoglycaemic and anti-inflammatory activity. Furthermore, clinical trials are needed to explore the medicative potential of papaya leaf. [Figure not available: see fulltext.].
KW - Carica papaya. Anticancer. Anti-inflammatory. Immunomodulatory. Phytochemical
UR - http://www.scopus.com/inward/record.url?scp=85085152700&partnerID=8YFLogxK
U2 - 10.1007/s40199-020-00348-7
DO - 10.1007/s40199-020-00348-7
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C2 - 32367410
AN - SCOPUS:85085152700
SN - 1560-8115
VL - 28
SP - 735
EP - 744
JO - DARU, Journal of Pharmaceutical Sciences
JF - DARU, Journal of Pharmaceutical Sciences
IS - 2
ER -
