TY - JOUR
T1 - The yin and yang of bacterial Asn in tumor biology
AU - Lobel, Lior
N1 - Publisher Copyright:
© 2025 Elsevier Inc.
PY - 2026/1/14
Y1 - 2026/1/14
N2 - In this issue of Cell Host & Microbe , Qiao et al. show that Bacteroides asparaginase reshapes anti-tumor immunity. When bacteria deplete asparagine, CD8⁺ T cells lose stemness and effector capacity, promoting tumor progression and weakening anti-PD-1 therapy. Deleting asparaginase restores asparagine to the tumor, enhancing anti-tumor immunity and immunotherapy.
AB - In this issue of Cell Host & Microbe , Qiao et al. show that Bacteroides asparaginase reshapes anti-tumor immunity. When bacteria deplete asparagine, CD8⁺ T cells lose stemness and effector capacity, promoting tumor progression and weakening anti-PD-1 therapy. Deleting asparaginase restores asparagine to the tumor, enhancing anti-tumor immunity and immunotherapy.
UR - https://www.scopus.com/pages/publications/105027705453
U2 - 10.1016/j.chom.2025.12.011
DO - 10.1016/j.chom.2025.12.011
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C2 - 41539298
AN - SCOPUS:105027705453
SN - 1931-3128
VL - 34
SP - 7
EP - 8
JO - Cell Host and Microbe
JF - Cell Host and Microbe
IS - 1
ER -