The yeast forkhead HCM1 controls life span independent of calorie restriction

Noam Maoz, Orshay Gabay, Hiba Waldman Ben-Asher, Haim Y. Cohen

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Regulation of life span by members of the forkhead transcription factor family of proteins is one of the most highly investigated pathways in the field of aging. Nevertheless, despite the existence of forkhead family homologues in yeast, our knowledge of these proteins' role in yeast longevity is limited. Here, we show that yeast Hcm1p forkhead is the closest homologue of the worm PHA-4 forkhead, which regulates Caenorhabditis elegans life span. Overexpressing the yeast forkhead HCM1 or its deficiency resulted in a significant extension or reduction in yeast replicative life span, respectively. HCM1 regulates stress resistance, significantly increases the mRNA levels of several stress response genes including the catalase enzymes CTA1 and CTT1, and positively regulates life span independently of calorie restriction. Thus, HCM1 is a key regulator of life span, through a mechanism independent of calorie restriction.

Original languageEnglish
Pages (from-to)444-453
Number of pages10
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume70
Issue number4
DOIs
StatePublished - 1 Apr 2015

Bibliographical note

Publisher Copyright:
© 2014 The Author.

Funding

Funding This study was supported by the Israel Science Foundation (62113), I-Core Foundation (41/11), Israeli Ministry of Health (3-9194), Teva Pharmaceutical Industries LTD (1237680), and the ERC: European Research Council (242763).

FundersFunder number
I-Core Foundation41/11
Teva Pharmaceutical Industries1237680
European Research Council242763
Israel Science Foundation62113
Ministry of Health, State of Israel3-9194

    Keywords

    • Aging
    • Forkhead
    • HCM1

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