The Tomato yellow leaf curl virus (TYLCV) V2 protein inhibits enzymatic activity of the host papain-like cysteine protease CYP1

Amalia Bar-Ziv, Yael Levy, Vitaly Citovsky, Yedidya Gafni

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

The viral V2 protein is one of the key factors that Tomato yellow leaf curl geminivirus (TYLCV), a major tomato pathogen worldwide, utilizes to combat the host defense. Besides suppressing the plant RNA silencing defense by targeting the host SGS3 component of the silencing machinery, V2 also interacts with the host CYP1 protein, a papain-like cysteine protease likely involved in hypersensitive response reactions. The biological effects of the V2-CYP1 interaction, however, remain unknown. We addressed this question by demonstrating that V2 inhibits the enzymatic activity of CYP1, but does not interfere with post-translational maturation of this protein.

Original languageEnglish
Pages (from-to)525-529
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume460
Issue number3
DOIs
StatePublished - 8 May 2015

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Inc.

Keywords

  • CYP1
  • Papain-like cysteine protease
  • Programmed cell death
  • TYLCV
  • V2 protein

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