The temporal behavior of the murine T cell receptor repertoire following Immunotherapy

Tom Snir, Hagit Philip, Miri Gordin, Alona Zilberberg, Sol Efroni

Research output: Contribution to journalArticlepeer-review

Abstract

Immunotherapy is now an essential tool for cancer treatment, and the unique features of an individual’s T cell receptor repertoire are known to play a key role in its effectiveness. The repertoire, famously vast due to a cascade of cellular mechanisms, can be quantified using repertoire sequencing. In this study, we sampled the repertoire over several time points following treatment with anti-CTLA-4, in a syngeniec mouse model for colorectal cancer, generating a longitudinal dataset of T cell clones and their abundance. The dynamics of the repertoire can be observed in response to treatment over a period of four weeks, as clonal expansion of specific clones ascends and descends. The data made available here can be used to determine treatment and predict its effect, while also providing a unique look at the behavior of the immune system over time.

Original languageEnglish
Article number108
JournalScientific data
Volume10
Issue number1
DOIs
StatePublished - 23 Feb 2023

Bibliographical note

Publisher Copyright:
© 2023, The Author(s).

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